“Agmatine deiminase”的意思、由来-开放百科全书

词条

Agmatine deiminase

释义

Structural studies
References

{{enzyme
| Name = agmatine deiminase
| EC_number = 3.5.3.12
| CAS_number = 37289-17-1
| IUBMB_EC_number = 3/5/3/12
| GO_code = 0047632
| image =
| width =
| caption =
}}

In enzymology, an agmatine deiminase ({{EC number|3.5.3.12}}) is an enzyme that catalyzes the chemical reaction

agmatine + H₂O N-carbamoylputrescine + NH₃

Thus, the two substrates of this enzyme are agmatine and H₂O, whereas its two products are N-carbamoylputrescine and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is agmatine iminohydrolase. This enzyme is also called agmatine amidinohydrolase. This enzyme participates in urea cycle and metabolism of amino groups.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1VKP}}, {{PDB link|2EWO}}, {{PDB link|2JER}}, and {{PDB link|2Q3U}}.

References

{{cite journal | author = Smith TA | date = 1969 | title = Agmatine iminohydrolase in maize | journal = Phytochemistry | volume = 8 | pages = 2111–2117 | doi = 10.1016/S0031-9422(00)88168-6 | issue = 11 }}
{{cite journal |vauthors=Srivenugopal KS, Adiga PR | date = 1981 | title = Enzymic conversion of agmatine to putrescine in Lathyrus sativus seedlings. Purification and properties of a multifunctional enzyme (putrescine synthase) | journal = J. Biol. Chem. | volume = 256 | pages = 9532–41 | pmid = 6895223 | issue = 18 }}

{{Carbon-nitrogen non-peptide hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{3.5-enzyme-stub}}

2 : EC 3.5.3|Enzymes of known structure

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