| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}1-acyl-sn-glycerol-3-phosphate acyltransferase alpha is an enzyme that in humans is encoded by the AGPAT1 gene.[1][2][3]This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein.[3] References1. ^{{cite journal | vauthors = Aguado B, Campbell RD | title = Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex | journal = J Biol Chem | volume = 273 | issue = 7 | pages = 4096–105 |date=Mar 1998 | pmid = 9461603 | pmc = | doi =10.1074/jbc.273.7.4096 }}
2. ^{{cite journal | vauthors = Stamps AC, Elmore MA, Hill ME, Kelly K, Makda AA, Finnen MJ | title = A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases | series = 326 | journal = Biochem J | volume = ( Pt 2) | issue = | pages = 455–61 |date=Sep 1997 | pmid = 9291118 | pmc = 1218691 | doi = }}
3. ^1 {{cite web | title = Entrez Gene: AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10554| accessdate = }}
External links- {{UCSC gene info|AGPAT1}}
Further reading{{refbegin | 2}}- {{cite journal | author=Leung DW |title=The structure and functions of human lysophosphatidic acid acyltransferases. |journal=Front. Biosci. |volume=6 |issue= 1|pages= D944–53 |year= 2001 |pmid= 11487472 |doi=10.2741/Leung }}
- {{cite journal | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
- {{cite journal | vauthors=Yu W, Andersson B, Worley KC |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |display-authors=etal}}
- {{cite journal | vauthors=West J, Tompkins CK, Balantac N |title=Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. |journal=DNA Cell Biol. |volume=16 |issue= 6 |pages= 691–701 |year= 1997 |pmid= 9212163 |doi= 10.1089/dna.1997.16.691|display-authors=etal}}
- {{cite journal | vauthors=Aguado B, Campbell RD |title=Human lysophosphatidic acid acyltransferase is encoded by a gene located in the major histocompatibility complex. |journal=Biochem. Soc. Trans. |volume=25 |issue= 4 |pages= S597 |year= 1998 |pmid= 9450025 |doi= }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |display-authors=etal}}
- {{cite journal | vauthors=Xie T, Rowen L, Aguado B |title=Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621–36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 | pmc=403804 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Servillo L, Balestrieri C, Giovane A |title=Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages. |journal=FASEB J. |volume=20 |issue= 7 |pages= 1015–7 |year= 2006 |pmid= 16571775 |doi= 10.1096/fj.05-5059fje |display-authors=etal}}
- {{cite journal | vauthors=Lloyd EE, Gaubatz JW, Burns AR, Pownall HJ |title=Sustained elevations in NEFA induce cyclooxygenase-2 activity and potentiate THP-1 macrophage foam cell formation. |journal=Atherosclerosis |volume=192 |issue= 1 |pages= 49–55 |year= 2007 |pmid= 16870193 |doi= 10.1016/j.atherosclerosis.2006.06.014 }}
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