| 释义 |
- Function
- References
- External links
- Further reading
{{Infobox_gene}}Glycerol-3-phosphate acyltransferase 3 (GPAT-3) is an enzyme that in humans is encoded by the AGPAT9 gene.[1][2][2][3] GPAT-3 is also known as: - 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9),
- lysophosphatidic acid acyltransferase theta (LPAAT-theta), or
- lung cancer metastasis-associated protein 1.
Function Glycerol-3-phosphate (G3P) acyltransferases (GPAT; EC 2.3.1.15), such as GPAM and GPAT3 (this enzyme), catalyze the initial step of de novo triacylglycerol (TAG) synthesis by converting glycerol-3-phosphate (G3P) to lysophosphatidic acid (LPA).[4] References1. ^{{cite journal | vauthors = Clark HF, Gurney AL, Abaya E | title = The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment | journal = Genome Res. | volume = 13 | issue = 10 | pages = 2265–70 |date=October 2003 | pmid = 12975309 | pmc = 403697 | doi = 10.1101/gr.1293003 | url = |display-authors=etal}}
2. ^{{cite journal | vauthors = Tang W, Yuan J, Chen X, Gu X, Luo K, Li J, Wan B, Wang Y, Yu L | title = Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway | journal = J. Biochem. Mol. Biol. | volume = 39 | issue = 5 | pages = 626–35 |date=September 2006 | pmid = 17002884 | doi = 10.5483/BMBRep.2006.39.5.626| url = }}
3. ^{{cite web | title = Entrez Gene: AGPAT9: 1-acylglycerol-3-phosphate O-acyltransferase 9 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84803| accessdate = }}
4. ^1 {{cite journal | vauthors = Cao J, Li JL, Li D, Tobin JF, Gimeno RE | title = Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 52 | pages = 19695–700 |date=December 2006 | pmid = 17170135 | pmc = 1702318 | doi = 10.1073/pnas.0609140103 | url = }}
External linksFurther reading{{refbegin | 2}}- {{cite journal | vauthors=Tang W, Yuan J, Chen X |title=Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway |journal=J. Biochem. Mol. Biol. |volume=39 |issue= 5 |pages= 626–35 |year= 2006 |pmid= 17002884 |doi=10.5483/BMBRep.2006.39.5.626 |display-authors=etal}}
- {{cite journal | vauthors=Yamada S, Ohira M, Horie H |title=Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas |journal=Oncogene |volume=23 |issue= 35 |pages= 5901–11 |year= 2004 |pmid= 15221005 |doi= 10.1038/sj.onc.1207782 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|display-authors=etal}}
- {{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
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