| 词条 | Ajmalicine |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 477316195 | IUPAC_name = (19α)-16,17-didehydro- 19-methyloxayohimban- 16-carboxylic acid methyl ester | image = Ajmalicine.png | tradename = | pregnancy_category = | legal_status = Rx-only | routes_of_administration = Oral | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 483-04-5 | ATC_prefix = none | ATC_suffix = | ChEBI = 2524 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 123325 | PubChem = 251561 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 390541 | C=21 | H=24 | N=2 | O=3 | molecular_weight = 352.43 g/mol | smiles = O=C(OC)\\C4=C\\OC(C5CN3CCc1c([nH]c2ccccc12)C3CC45)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = GRTOGORTSDXSFK-XJTZBENFSA-N | melting_point = 262.5 | melting_high = 263 }}Ajmalicine, also known as δ-yohimbine or raubasine, is an antihypertensive drug used in the treatment of high blood pressure.[1] It has been marketed under numerous brand names including Card-Lamuran, Circolene, Cristanyl, Duxil, Duxor, Hydroxysarpon, Iskedyl, Isosarpan, Isquebral, Lamuran, Melanex, Raunatin, Saltucin Co, Salvalion, and Sarpan.[1] It is also an alkaloid found naturally in various plants such as Rauwolfia spp., Catharanthus roseus, and Mitragyna speciosa.[1][2][3] Ajmalicine is structurally related to yohimbine, rauwolscine, and other yohimban derivatives. Like corynanthine, it acts as a α1-adrenergic receptor antagonist with preferential actions over α2-adrenergic receptors, underlying its hypotensive rather than hypertensive effects.[1][4] See also
References1. ^1 2 3 {{cite book | author = Wink, Michael | author2 = Roberts, M. W. | title = Alkaloids: biochemistry, ecology, and medicinal applications | publisher = Plenum Press | location = New York | year = 1998 | pages = | isbn = 0-306-45465-3 | oclc = | doi = | url = https://books.google.com/books?id=bMCzyrAtrvYC&lpg=PA450&dq=ajmalicine&as_brr=3&pg=PA451#v=onepage&q=&f=false}} {{Antihypertensives}}{{Adrenergics}}{{antihypertensive-stub}}2. ^{{cite journal | vauthors = Kurz WG, Chatson KB, Constabel F | title = Alkaloid Production in Catharanthus roseus Cell Cultures VIII1 | journal = Planta Medica | volume = 42 | issue = 5 | pages = 22–31 |date=May 1981 | pmid = 17401876 | doi = 10.1055/s-2007-971541 | url = http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-971541|display-authors=etal}} 3. ^{{cite journal | vauthors = León F, Habib E, Adkins JE, Furr EB, McCurdy CR, Cutler SJ | title = Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A | journal = Natural Product Communications | volume = 4 | issue = 7 | pages = 907–10 |date=July 2009 | pmid = 19731590 | doi = | url = }} 4. ^{{cite journal | vauthors = Roquebert J, Demichel P | title = Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine | journal = European Journal of Pharmacology | volume = 106 | issue = 1 | pages = 203–5 |date=October 1984 | pmid = 6099269 | doi = 10.1016/0014-2999(84)90698-8| url = }} 5 : Alpha blockers|Antihypertensive agents|Indole alkaloids|Vinca alkaloids|Alkaloids found in Rauvolfia |
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