| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene.[1][2][3]This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.[4] References1. ^{{cite journal | vauthors = Hyndman DJ, Flynn TG | title = Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family | journal = Biochim Biophys Acta | volume = 1399 | issue = 2–3 | pages = 198–202 |date=Oct 1998 | pmid = 9765596 | pmc = | doi = 10.1016/s0167-4781(98)00109-2}}
2. ^{{cite journal | vauthors = Cao D, Fan ST, Chung SS | title = Identification and characterization of a novel human aldose reductase-like gene | journal = J Biol Chem | volume = 273 | issue = 19 | pages = 11429–35 |date=Jun 1998 | pmid = 9565553 | pmc = | doi =10.1074/jbc.273.19.11429 }}
3. ^{{cite web | title = Entrez Gene: AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57016| accessdate = }}
4. ^{{cite web | title = Entrez Gene: AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57016| accessdate = }}
External links- {{UCSC gene info|AKR1B10}}
- {{UCSC gene info|ARL1}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Scuric Z, Stain SC, Anderson WF, Hwang JJ |title=New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma |journal=Hepatology |volume=27 |issue= 4 |pages= 943–50 |year= 1998 |pmid= 9537432 |doi= 10.1002/hep.510270408 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Crosas B, Hyndman DJ, Gallego O |title=Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism |journal=Biochem. J. |volume=373 |issue= Pt 3 |pages= 973–9 |year= 2003 |pmid= 12732097 |doi= 10.1042/BJ20021818 | pmc=1223539 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Petrovic MG, Peterlin B, Hawlina M, Petrovic D |title=Aldose reductase (AC)n gene polymorphism and susceptibility to diabetic retinopathy in Type 2 diabetes in Caucasians |journal=J. Diabetes Complicat. |volume=19 |issue= 2 |pages= 70–3 |year= 2005 |pmid= 15745835 |doi= 10.1016/j.jdiacomp.2004.08.004 }}
- {{cite journal | vauthors=Kang ES, Kim HJ, Paek KS |title=Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation |journal=Cell. Mol. Life Sci. |volume=62 |issue= 10 |pages= 1146–55 |year= 2005 |pmid= 15928807 |doi= 10.1007/s00018-005-5024-4 |display-authors=etal}}
- {{cite journal | vauthors=Lee YS, Paek KS, Kang ES |title=Involvement of nuclear factor kappaB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa cells |journal=Int. J. Biochem. Cell Biol. |volume=37 |issue= 11 |pages= 2297–309 |year= 2005 |pmid= 15936242 |doi= 10.1016/j.biocel.2005.04.016 |display-authors=etal}}
- {{cite journal | vauthors=Vikramadithyan RK, Hu Y, Noh HL |title=Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice |journal=J. Clin. Invest. |volume=115 |issue= 9 |pages= 2434–43 |year= 2005 |pmid= 16127462 |doi= 10.1172/JCI24819 | pmc=1190371 |display-authors=etal}}
- {{cite journal | vauthors=Hazemann I, Dauvergne MT, Blakeley MP |title=High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase |journal=Acta Crystallogr. D |volume=61 |issue= Pt 10 |pages= 1413–7 |year= 2005 |pmid= 16204895 |doi= 10.1107/S0907444905024285 |display-authors=etal}}
- {{cite journal | vauthors=Mashkova TD, ((Oparina NIu)), Zinov'eva OL |title=[Transcription TIMP3, DAPk1 and AKR1B10 genes in squamous cell lung cancer] |journal=Mol. Biol. (Mosk.) |volume=40 |issue= 6 |pages= 1047–54 |year= 2007 |pmid= 17209433 |doi= 10.1134/s0026893306060148|display-authors=etal}}
- {{cite journal | vauthors=Tammali R, Ramana KV, Srivastava SK |title=Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells |journal=Cancer Lett. |volume=252 |issue= 2 |pages= 299–306 |year= 2007 |pmid= 17300864 |doi= 10.1016/j.canlet.2007.01.001 | pmc=1945127 }}
- {{cite journal | vauthors=Yan R, Zu X, Ma J |title=Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention |journal=Int. J. Cancer |volume=121 |issue= 10 |pages= 2301–6 |year= 2007 |pmid= 17597105 |doi= 10.1002/ijc.22933 |display-authors=etal}}
{{refend}}{{PDB Gallery|geneid=57016}}{{Alcohol oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{protein-stub}} 1 : EC 1.1.1 |