“AKR1C3”的意思、由来-开放百科全书

Function

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.^[3]

Pathology

AKR1C3 is overexpressed in prostate cancer (PCa) and is associated with the development of castration-resistant prostate cancer (CRPC). In addition, AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression.^[4]

References

1. ^{{cite journal | vauthors = Khanna M, Qin KN, Wang RW, Cheng KC | title = Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases | journal = The Journal of Biological Chemistry | volume = 270 | issue = 34 | pages = 20162–8 | date = Aug 1995 | pmid = 7650035 | pmc = | doi = 10.1074/jbc.270.34.20162 }}
2. ^{{cite journal | vauthors = Matsuura K, Shiraishi H, Hara A, Sato K, Deyashiki Y, Ninomiya M, Sakai S | title = Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity | journal = Journal of Biochemistry | volume = 124 | issue = 5 | pages = 940–6 | date = Nov 1998 | pmid = 9792917 | pmc = | doi = 10.1093/oxfordjournals.jbchem.a022211 }}
3. ^¹{{cite web | title = Entrez Gene: AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8644| accessdate = }}
4. ^{{cite journal | vauthors = Tian Y, Zhao L, Zhang H, Liu X, Zhao L, Zhao X, Li Y, Li J | title = AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression | journal = Diagnostic Pathology | volume = 9 | issue = 1 | pages = 42 | year = 2014 | pmid = 24571686 | pmc = 3939640 | doi = 10.1186/1746-1596-9-42 }}

Further reading

{{cite journal | vauthors = Lin SX, Shi R, Qiu W, Azzi A, Zhu DW, Dabbagh HA, Zhou M | title = Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5 | journal = Molecular and Cellular Endocrinology | volume = 248 | issue = 1-2 | pages = 38–46 | date = Mar 2006 | pmid = 16480815 | doi = 10.1016/j.mce.2005.11.035 }}

{{cite journal | vauthors = Khanna M, Qin KN, Cheng KC | title = Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans | journal = The Journal of Steroid Biochemistry and Molecular Biology | volume = 53 | issue = 1-6 | pages = 41–6 | date = Jun 1995 | pmid = 7626489 | doi = 10.1016/0960-0760(95)00019-V }}

{{cite journal | vauthors = Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H | title = Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 2 | issue = 1 | pages = 37–43 | year = 1995 | pmid = 7788527 | doi = 10.1093/dnares/2.1.37 }}

{{cite journal | vauthors = Khanna M, Qin KN, Klisak I, Belkin S, Sparkes RS, Cheng KC | title = Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization | journal = Genomics | volume = 25 | issue = 2 | pages = 588–90 | date = Jan 1995 | pmid = 7789999 | doi = 10.1016/0888-7543(95)80066-U }}

{{cite journal | vauthors = Qin KN, New MI, Cheng KC | title = Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase | journal = The Journal of Steroid Biochemistry and Molecular Biology | volume = 46 | issue = 6 | pages = 673–9 | date = Dec 1993 | pmid = 8274401 | doi = 10.1016/0960-0760(93)90308-J }}

{{cite journal | vauthors = Bennett MJ, Schlegel BP, Jez JM, Penning TM, Lewis M | title = Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+ | journal = Biochemistry | volume = 35 | issue = 33 | pages = 10702–11 | date = Aug 1996 | pmid = 8718859 | doi = 10.1021/bi9604688 }}

{{cite journal | vauthors = Lin HK, Jez JM, Schlegel BP, Peehl DM, Pachter JA, Penning TM | title = Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution | journal = Molecular Endocrinology | volume = 11 | issue = 13 | pages = 1971–84 | date = Dec 1997 | pmid = 9415401 | doi = 10.1210/me.11.13.1971 }}

{{cite journal | vauthors = Mills KI, Gilkes AF, Sweeney M, Choudhry MA, Woodgate LJ, Bunce CM, Brown G, Burnett AK | title = Identification of a retinoic acid responsive aldoketoreductase expressed in HL60 leukaemic cells | journal = FEBS Letters | volume = 440 | issue = 1-2 | pages = 158–62 | date = Nov 1998 | pmid = 9862446 | doi = 10.1016/S0014-5793(98)01435-5 }}

{{cite journal | vauthors = Dufort I, Rheault P, Huang XF, Soucy P, Luu-The V | title = Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase | journal = Endocrinology | volume = 140 | issue = 2 | pages = 568–74 | date = Feb 1999 | pmid = 9927279 | doi = 10.1210/en.140.2.568 }}

{{cite journal | vauthors = Rheault P, Dufort I, Soucy P, Luu-The V | title = Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship | journal = Cytogenetics and Cell Genetics | volume = 84 | issue = 3-4 | pages = 241–2 | year = 1999 | pmid = 10393440 | doi = 10.1159/000015267 }}

{{cite journal | vauthors = Griffin LD, Mellon SH | title = Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 23 | pages = 13512–7 | date = Nov 1999 | pmid = 10557352 | pmc = 23979 | doi = 10.1073/pnas.96.23.13512 }}

{{cite journal | vauthors = Suzuki-Yamamoto T, Nishizawa M, Fukui M, Okuda-Ashitaka E, Nakajima T, Ito S, Watanabe K | title = cDNA cloning, expression and characterization of human prostaglandin F synthase | journal = FEBS Letters | volume = 462 | issue = 3 | pages = 335–40 | date = Dec 1999 | pmid = 10622721 | doi = 10.1016/S0014-5793(99)01551-3 }}

{{cite journal | vauthors = Nishizawa M, Nakajima T, Yasuda K, Kanzaki H, Sasaguri Y, Watanabe K, Ito S | title = Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes | journal = Genes to Cells | volume = 5 | issue = 2 | pages = 111–25 | date = Feb 2000 | pmid = 10672042 | doi = 10.1046/j.1365-2443.2000.00310.x }}

{{cite journal | vauthors = Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, Moore M, Palackal N, Ratnam K | title = Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones | journal = The Biochemical Journal | volume = 351 | issue = Pt 1 | pages = 67–77 | date = Oct 2000 | pmid = 10998348 | pmc = 1221336 | doi = 10.1042/0264-6021:3510067 }}

{{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}

{{cite journal | vauthors = Penning TM, Burczynski ME, Jez JM, Lin HK, Ma H, Moore M, Ratnam K, Palackal N | title = Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) | journal = Molecular and Cellular Endocrinology | volume = 171 | issue = 1-2 | pages = 137–49 | date = Jan 2001 | pmid = 11165022 | doi = 10.1016/S0303-7207(00)00426-3 }}

{{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}

1 : EC 1.1.1

Function

Pathology

References

External links

Further reading