| 词条 | AL-37350A |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477346561 | IUPAC_name = (S)-(+)-1-(2-Aminopropyl)-8,9-dihydropyrano[3,2-e]indole | image = AL-37350A_structure.png | width = 140 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 362603-40-5 | ATC_prefix = | ATC_suffix = | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 133455 | PubChem = 10331436 | IUPHAR_ligand = 160 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 8506896 | C=14 | H=18 | N=2 | O=1 | molecular_weight = 230.305 g/mol | smiles = O2c1ccc3c(c1CCC2)c(c[nH]3)C[C@@H](N)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C14H18N2O/c1-9(15)7-10-8-16-12-4-5-13-11(14(10)12)3-2-6-17-13/h4-5,8-9,16H,2-3,6-7,15H2,1H3/t9-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = VVHJUSGIUWQPIT-VIFPVBQESA-N | melting_point = | melting_high = }}AL-37350A (4,5-DHP-AMT) is a tryptamine derivative which acts as a potent and selective agonist for the serotonin receptor 5-HT2A, with a Ki of 2.0 nM, and moderate selectivity over the related 5-HT2B and 5-HT2C receptors. It has been shown to have ocular hypotensive activity in animal models, suggesting it may be useful for the treatment of glaucoma.[1] See also
References1. ^{{cite journal |vauthors =May JA, Chen HH, Rusinko A, Lynch VM, Sharif NA, McLaughlin MA |title=A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole |journal=Journal of Medicinal Chemistry |volume=46 |issue=19 |pages=4188–95 |date=September 2003 |pmid=12954071 |doi=10.1021/jm030205t |url=|citeseerx=10.1.1.688.6169 }} {{Hallucinogens}}{{Serotonergics}}{{Tryptamines}}{{nervous-system-drug-stub}} 3 : Dihydropyrans|Serotonin receptor agonists|Tryptamines |
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