| 词条 | AL-38022A |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 462571437 | IUPAC_name = (S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine | image = AL-38022A_structure.png | width = 180 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 478132-11-5 | ATC_prefix = | ATC_suffix = | PubChem = 22496603 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 26286943 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C13H17N3O/c1-9(14)8-16-13-10(7-15-16)4-5-12-11(13)3-2-6-17-12/h4-5,7,9H,2-3,6,8,14H2,1H3/t9-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = FJRIVFVALIEIOY-VIFPVBQESA-N | C=13 | H=17 | N=3 | O=1 | molecular_weight = 231.293 g/mol | smiles = c13CCCOc3ccc(cn2)c1n2CC(C)N | melting_point = 106 | melting_high = 107 }}AL-38022A is an indazole derivative drug which is one of a range of similar drugs developed for scientific research and with some possible clinical applications. It acts as a potent and selective agonist for the 5-HT2 family of serotonin receptors, with highest binding affinity for the 5-HT2C subtype and around 4x less affinity for 5-HT2A and 5-HT2B. In drug discrimination tests on animals, it fully substituted for both DOM and 5-MeO-DMT.[1] See also
References1. ^{{cite journal | last1 = May | first1 = JA | last2 = Sharif | first2 = NA | last3 = Chen | first3 = HH | last4 = Liao | first4 = JC | last5 = Kelly | first5 = CR | last6 = Glennon | first6 = RA | last7 = Young | first7 = R | last8 = Li | first8 = JX | last9 = Rice | first9 = KC | last10 = France | first10 = CP | title = Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A (S)-2-(8,9-dihydro-7H-pyrano2,3-gindazol-1-yl)-1-methylethylamine | journal = Pharmacology Biochemistry and Behavior | volume = 91 | issue = 3 | pages = 307–14 | year = 2009 | pmid = 18718483 | doi = 10.1016/j.pbb.2008.07.015 | pmc = 3763814 }} {{Hallucinogens}}{{Serotonergics}}{{nervous-system-drug-stub}}{{Amine-stub}} 4 : Amines|Indazoles|Dihydropyrans|Serotonin receptor agonists |
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