| 词条 | Alan Ashworth |
| 释义 |
| name = Alan Ashworth | native_name = | native_name_lang = | image = | image_size = | alt = | caption = | birth_date = {{birth year and age|1960}} | birth_place = Bolton, Lancashire | death_date = | signature_alt = | website = {{URL|http://cancer.ucsf.edu/people/profiles/ashworth_alan/}} | footnotes = | spouse = | children = }}Alan Ashworth, FRS (born 1960 in Bolton, Lancashire) is a British molecular biologist, noted for his work on genes involved in cancer susceptibility. He is currently the President of the UCSF Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco, a multidisciplinary research and clinical care organisation that is one of the largest cancer centres in the Western United States.[1] He was previously CEO of the Institute of Cancer Research (ICR) in London.[2] Early lifeAshworth was educated at St Mary's Primary School and Thornleigh Salesian College, Bolton. He completed his Bachelor of Science in Chemistry and Biochemistry at Imperial College, London, and was awarded a PhD in Biochemistry at University College, London.[3] CareerAshworth joined the Institute for Cancer Research (ICR) in London in 1986 as a Postdoctoral research Scientist in the Section of Cell and Molecular Biology and in 1999 he was appointed the first Director of the Breakthrough Breast Cancer Research Centre (BBCRC).[4] The Centre is now recognised internationally and has more than 120 scientists and researchers working on aspects of the disease ranging from basic molecular and cellular biology through to translational research and clinical trials.[4] Ashworth's Directorship ended in January 2011 when he took up the position of Chief Executive of the ICR which he held until December 2014.[5] One of Ashworth's major contributions to cancer research has been his work on genes involved in cancer risk. He was a key part of the team that in 1995 discovered the BRCA2 gene,[6][7][8][9] which is linked to an increased risk of some types of cancers[10]/ which is now used to identify women at high risk of the disease. Ten years later, Ashworth identified a way to exploit genetic weaknesses in cancer cells including mutated BRCA 1 or BRCA2, leading to a new approach to work on Poly ADP ribose polymerase (PARP as a drug target for cancer.[11][12] Ashworth's research and leadership reflects his passion for translating laboratory studies into improvements in patient care, particularly by the development of personalised cancer medicine.[13][14] In 2014, Ashworth stepped down as Director of the ICR to join the University of California, San Francisco as President of the UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC) and Senior Vice-President of Cancer Services of UCSF Health from January 2015.[15] He also serves as Professor of Medicine, Division of Hematology/Oncology, Department of Medicine and holds the E. Dixon Heise Distinguished Professorship in Oncology.[16] In 2016, Ashworth and Pamela Munster, MD, established the UCSF [https://www.wsj.com/articles/brca-clinics-expand-further-beyond-breast-cancer-1456170654 Center for BRCA Research]. In November 2016 he started the [https://www.bizjournals.com/sanfrancisco/news/2016/11/16/sf-can-ucsf-kaiser-cancer-liver-prostate-breast.html San Francisco Cancer Initiative (SF CAN)]. In 2017, he became inaugural chair of the University of California Cancer Consortium. Awards and recognition
References1. ^{{cite web|url = http://cancer.ucsf.edu/people/profiles/ashworth_alan|publisher = UCSF Helen Diller Family Comprehensive Cancer Center|title = Research profiles: Professor Alan Ashworth FRS }} 2. ^{{cite web |url = http://www.icr.ac.uk/about_us/management_structure/index.shtml|publisher = The Institute of Cancer Research|title = Management structure|accessdate=2011-06-12| archiveurl= https://web.archive.org/web/20110610233041/http://www.icr.ac.uk/about_us/management_structure/index.shtml| archivedate=2011-06-10 | deadurl= no}} 3. ^{{Cite web |url=http://www.oncologynews.biz/pdf/oct_nov/ON_ON06_11.pdf |title=Archived copy |access-date=15 June 2011 |archive-url=https://web.archive.org/web/20120325180034/http://www.oncologynews.biz/pdf/oct_nov/ON_ON06_11.pdf |archive-date=25 March 2012 |dead-url=yes |df=dmy-all }} 4. ^1 {{Cite web |url=http://www.icr.ac.uk/press/press_archive/press_releases_2009/13987.shtml |title=Archived copy |access-date=28 January 2010 |archive-url=https://web.archive.org/web/20110610221208/http://www.icr.ac.uk/press/press_archive/press_releases_2009/13987.shtml |archive-date=10 June 2011 |dead-url=yes |df=dmy-all }} 5. ^{{Cite web |url=http://www.icr.ac.uk/press/recent_featured_articles/AA_starts_CE/16865.shtml |title=Archived copy |access-date=15 June 2011 |archive-url=https://web.archive.org/web/20110927051601/http://www.icr.ac.uk/press/recent_featured_articles/AA_starts_CE/16865.shtml |archive-date=27 September 2011 |dead-url=yes |df=dmy-all }} 6. ^{{Cite journal | pmid = 9579822| pmc = 2150153| year = 1998| author1 = Roth| first1 = S| title = A missense mutation in the BRCA2 gene in three siblings with ovarian cancer| journal = British Journal of Cancer| volume = 77| issue = 8| pages = 1199–202| last2 = Kristo| first2 = P| last3 = Auranen| first3 = A| last4 = Shayehgi| first4 = M| last5 = Seal| first5 = S| last6 = Collins| first6 = N| last7 = Barfoot| first7 = R| last8 = Rahman| first8 = N| authorlink8 = Nazneen Rahman| last9 = Klemi| first9 = P. 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M.| last8 = Freeman| first8 = T| last9 = Ashworth| first9 = A| authorlink9 = Alan Ashworth| doi = 10.1093/hmg/6.2.291}} 8. ^{{Cite journal | pmid = 9002670| year = 1997| author1 = Bignell| first1 = G| title = The BRC repeats are conserved in mammalian BRCA2 proteins| journal = Human Molecular Genetics| volume = 6| issue = 1| pages = 53–8| last2 = Micklem| first2 = G| last3 = Stratton| first3 = M. R.| last4 = Ashworth| first4 = A| last5 = Wooster| first5 = R | doi=10.1093/hmg/6.1.53}} 9. ^{{Cite journal | pmid = 8640235| year = 1996| author1 = Lancaster| first1 = J. M.| title = BRCA2 mutations in primary breast and ovarian cancers| journal = Nature Genetics| volume = 13| issue = 2| pages = 238–40| last2 = Wooster| first2 = R| last3 = Mangion| first3 = J| last4 = Phelan| first4 = C. 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A.| doi = 10.1038/ng0696-238}} 10. ^{{Cite journal | last1 = Wooster | first1 = R. | last2 = Bignell | first2 = G. | last3 = Lancaster | first3 = J. | last4 = Swift | first4 = S. | last5 = Seal | first5 = S. | last6 = Mangion | first6 = J. | last7 = Collins | first7 = N. | last8 = Gregory | first8 = S. | last9 = Gumbs | first9 = C. | last10 = Micklem | doi = 10.1038/378789a0 | first10 = G. | last11 = Barfoot | first11 = R. | last12 = Hamoudi | first12 = R. | last13 = Patel | first13 = S. | last14 = Rices | first14 = C. | last15 = Biggs | first15 = P. | last16 = Hashim | first16 = Y. | last17 = Smith | first17 = A. | last18 = Connor | first18 = F. | last19 = Arason | first19 = A. | last20 = Gudmundsson | first20 = J. | last21 = Ficenec | first21 = D. | last22 = Kelsell | first22 = D. | last23 = Tonin | first23 = P. | last24 = Timothy Bishop | first24 = D. | last25 = Spurr | first25 = N. K. | last26 = Ponder | first26 = B. A. J. | last27 = Eeles | first27 = R. | last28 = Peto | first28 = J. | last29 = Devilee | first29 = P. | last30 = Cornelisse | first30 = C. | title = Identification of the breast cancer susceptibility gene BRCA2 | journal = Nature | volume = 378 | issue = 6559 | pages = 789–792 | year = 1995 | pmid = 8524414}} 11. ^{{Cite journal | pmid = 20110964| year = 2010| author1 = Cressey| first1 = D| title = Translational research: Talking up translation: Alan Ashworth took a cancer drug from Petri dish to patients in near record speed| journal = Nature| volume = 463| issue = 7280| pages = 422–3| doi = 10.1038/463422a}} 12. ^{{Cite journal | last1 = Wooster | first1 = R. | last2 = Neuhausen | first2 = S. | last3 = Mangion | first3 = J. | last4 = Quirk | first4 = Y. | last5 = Ford | first5 = D. | last6 = Collins | first6 = N. | last7 = Nguyen | first7 = K. | last8 = Seal | first8 = S. | last9 = Tran | first9 = T. | last10 = Averill | doi = 10.1126/science.8091231 | first10 = D. | last11 = Et | first11 = A. | title = Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13 | journal = Science | volume = 265 | issue = 5181 | pages = 2088–2090 | year = 1994 | pmid = 8091231}} 13. ^{{cite journal|url=http://www.nature.com/news/2010/100127/full/463422a.html|title=Translational research: Talking up translation|first=Daniel|last=Cressey|date=27 January 2010|journal=Nature News|volume=463|issue=7280|pages=422–423|accessdate=4 October 2017|via=www.nature.com|doi=10.1038/463422a}} 14. ^{{cite web|url=http://www.breakthroughgenerations.org.uk/whos_involved/the_study_team/the_study_2.html|title=Breakthrough Generations|website=Breakthroughgenerations.org.uk|accessdate=4 October 2017}} 15. ^{{cite web|url=http://cancer.ucsf.edu/news/2014/03/17/acclaimed-british-scientist-is-named-director-of-the-ucsf-helen-diller-family-comprehensive-cancer-center.5199|archiveurl=https://web.archive.org/web/20150402145923/http://cancer.ucsf.edu/news/2014/03/17/acclaimed-british-scientist-is-named-director-of-the-ucsf-helen-diller-family-comprehensive-cancer-center.5199|publisher=University of California, San Francisco|title=Acclaimed British Scientist Alan Ashworth Is Named Director of the UCSF Helen Diller Family Comprehensive Cancer Center|archivedate=2015-04-02}} 16. ^{{cite web|url=http://cancer.ucsf.edu/people/profiles/ashworth_alan|title=Alan Ashworth, PhD, FRS - UCSF Helen Diller Family Comprehensive Cancer Center|website=cancer.ucsf.edu|accessdate=4 October 2017}} 17. ^{{cite web|url = http://www.embo.org/embo-members/find-a-member.html|publisher =EMBO|title = Find an EMBO member (searchable database of members)|accessdate=2011-06-12| archiveurl= https://web.archive.org/web/20110722091839/http://www.embo.org/embo-members/find-a-member.html| archivedate=2011-07-22 | deadurl= no}} 18. ^{{cite web |url=http://www.acmedsci.ac.uk/p59fid4526.html |publisher=The Academy of Medical Science |title=Fellows: Professor Alan Ashworth FRS FMedSci |accessdate=2011-06-12 |deadurl=yes |archiveurl=https://web.archive.org/web/20110820105421/http://www.acmedsci.ac.uk/p59fid4526.html |archivedate=2011-08-20 |df= }} 19. ^{{cite web |url=http://www.royalsociety.org/General_WF.aspx?pageid=8951&terms=Alan+Ashworth#e |publisher=The Royal Society |title=New Fellows 08 Agarwal – Cohen – New Fellows 2008 – The Royal Society |accessdate=2010-01-27 |deadurl=yes |archiveurl=https://web.archive.org/web/20110811074424/http://royalsociety.org/General_WF.aspx?pageid=8951&terms=Alan+Ashworth |archivedate=2011-08-11 |df= }} 20. ^{{cite web|url = http://www.esmo.org/career-grants/awards/awardees.html|archive-url = https://archive.is/20110829045732/http://www.esmo.org/career-grants/awards/awardees.html|dead-url = yes|archive-date=2011-08-29|publisher = ESMO|title = awardees|accessdate=2011-06-12}} 21. ^{{cite web |url=http://www.europeancanceracademy.eu/europeancanceracademy/English/Fellows/Directory/page.aspx/1793 |publisher=European Academy of Cancer Sciences |title=Directory of Fellows |deadurl=yes |archiveurl=https://web.archive.org/web/20120325180033/http://www.europeancanceracademy.eu/europeancanceracademy/English/Fellows/Directory/page.aspx/1793 |archivedate=2012-03-25 |df= }} 22. ^{{cite web|url =http://www.waxmancancer.org/News-Resources/Press-Releases/Archive/2010-Alan-Ashworth|publisher = Samuel Waxman Cancer Research Foundation |title = Press release: Alan Ashworth To Receive Award for His Breakthrough Work in Breast Cancer}} 23. ^{{cite web|url=http://www.dkfz.de/en/presse/pressemitteilungen/2010/dkfz_pm_10_52-2010-Meyenburg-Award-for-Discoverer-of-BRCA-2-Breast-Cancer-Gene.php|title=2010 Meyenburg Award for Discoverer of BRCA 2 Breast Cancer Gene|website=Dkfz.de|accessdate=4 October 2017}} 24. ^{{cite web|url=https://www.pennmedicine.org/news/news-releases/2013/july/penns-basser-research-center-f|title=Penn's Basser Research Center for BRCA Names UK Breast Cancer Researcher Alan Ashworth Winner of First Annual Basser Global Prize – PR News|website=Pennmedicine.org|accessdate=4 October 2017}} 25. ^{{cite web|url=https://www.ucsf.edu/news/2015/06/129966/ashworth-receives-award-cancer-nonprofit|title=Ashworth Receives Award from Cancer Nonprofit|website=UC San Francisco|accessdate=4 October 2017}} 26. ^{{cite web|url=http://drexel.edu/medicine/about/departments/institute-for-molecular-medicine-infectious-disease/international-symposium/Prize-Winners/|title=International Symposium on Molecular Medicine & Infectious Disease Prize Winners - College of Medicine|website=Drexel.edu|accessdate=4 October 2017}} 27. ^{{cite web|url=http://www.aacr.org/AboutUs/Pages/BoardOfDirectors.aspx#.Wckh8dN97p4|title=Board of Directors|website=Aacr.org|accessdate=4 October 2017}} 28. ^{{citeweb|url=https://ww5.komen.org/WhatWeDo/AwardsandRecognition/AwardsRecognition.html|title=Brinker Awards|website=komen.org|accessdate=15 December 2017}} External links
10 : 1960 births|Living people|Fellows of the Royal Society|People from Bolton|British medical researchers|Academics of the Institute of Cancer Research|British molecular biologists|Alumni of Imperial College London|Alumni of University College London|University of California, San Francisco faculty |
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