Alexopoulos ({{lang-el|Αλεξόπουλος}}) is a Greek patronymic surname meaning "son of Alexios". The female form of the surname is Alexopoulou (Αλεξοπούλου). Notable people with the surname include:

• Alexios Alexopoulos, Greek sprinter
• Athina-Theodora Alexopoulou (born 1983), Greek sprint canoeist
• Georgios Alexopoulos, Greek footballer

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