| 词条 | Alfadolone |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 477317128 | IUPAC_name = (3R,5S,9S,14S)-3-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one | image = Alphadolone.svg | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = Intravenous | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 14107-37-0 | ATC_prefix = none | ATC_suffix = | PubChem = 71680 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 2104019 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 7974182 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = OE1C96974E | C=21 | H=32 | O=4 | molecular_weight = 348.476 g/mol | smiles = O=C2[C@H]3[C@H]([C@@H]1CC[C@H](C(=O)CO)[C@@]1(C)C2)CC[C@H]4C[C@H](O)CC[C@]34C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C21H32O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h12-16,19,22-23H,3-11H2,1-2H3/t12-,13+,14-,15-,16+,19+,20-,21-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = XWYBFXIUISNTQG-VKMGZQQJSA-N | synonyms = 3α,21-dihydroxy-5α-pregnane-11,20-dione }}Alfadolone (INN), or alphadolone is a neuroactive steroid and general anesthetic.[1] Along with alfaxolone, as alfadolone acetate, it is one of the components of the anesthetic drug mixture althesin.[1] Chemistry{{See also|List of neurosteroids}}See also
References1. ^1 {{cite book|author1=C.R. Ganellin|author2=David J. Triggle|title=Dictionary of Pharmacological Agents|url=https://books.google.com/books?id=A0THacd46ZsC&pg=PA1094|date=21 November 1996|publisher=CRC Press|isbn=978-0-412-46630-4|pages=1094–}} {{General anesthetics}}{{GABAAR PAMs}}{{nervous-system-drug-stub}} 4 : General anesthetics|Neurosteroids|GABAA receptor positive allosteric modulators|Pregnanes |
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