“Aliphatic nitrilase”的意思、由来-开放百科全书

词条

Aliphatic nitrilase

释义

References

{{enzyme
| Name = aliphatic nitrilase
| EC_number = 3.5.5.7
| CAS_number = 9024-90-2
| IUBMB_EC_number = 3/5/5/7
| GO_code = 0018762
| image =
| width =
| caption =
}}

In enzymology, an aliphatic nitrilase also known as aliphatic nitrile aminohydrolase ({{EC number|3.5.5.7}}) is an enzyme that catalyzes the hydrolysis of nitriles to carboxylic acids:

R-CN + 2 H₂O R-COOH + NH₃

Thus, the two substrates of this enzyme are an aliphatic nitrile (R-CN) and H₂O, whereas its two products are a carboxylic acid (R-COOH) and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. This enzyme participates in styrene degradation.

References

{{refbegin}}* {{cite journal | vauthors = Kobayashi M, Yanaka N, Nagasawa T, Yamada H | date = 1992 | title = Primary structure of an aliphatic nitrile-degrading enzyme, aliphatic nitrilase, from Rhodococcus rhodochrous K22 and expression of its gene and identification of its active site residue | journal = Biochemistry | volume = 31 | pages = 9000–7 | pmid = 1390687 | doi = 10.1021/bi00152a042 | issue = 37 }}

{{cite journal | vauthors = Pace HC, Brenner C | date = 2001 | title = The nitrilase superfamily: classification, structure and function | journal = Genome Biol. | volume = 2 | pages = REVIEWS0001 | pmid = 11380987 | issue = 1 | pmc = 150437 | doi=10.1186/gb-2001-2-1-reviews0001}}

{{refend}}{{Carbon-nitrogen non-peptide hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{3.5-enzyme-stub}}

2 : EC 3.5.5|Enzymes of unknown structure

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