| 词条 | Allan C. Spradling |
| 释义 |
|name = Allan C. Spradling |image = |image_size = |caption = Do you have a picture of Allan Spradling? Please, post here. |birth_date = {{Birth year and age|1949}} |birth_place = |death_date = |death_place = |residence = |citizenship = |nationality = |ethnicity = |fields = Genetics |workplaces = Carnegie Institution for Science, Howard Hughes Medical Institute |alma_mater = University of Chicago, Massachusetts Institute of Technology |doctoral_advisor = |academic_advisors = |doctoral_students = |notable_students = |known_for = |author_abbrev_bot = |author_abbrev_zoo = |influences = |influenced = |awards = {{no wrap|Newcomb Cleveland Prize {{small|(1983)}} Genetics Society of America Medal {{small|(1989)}} Edwin Grant Conklin Medal (2003) George W. Beadle Award {{small|(2003)}}[1] Gruber Prize in Genetics {{small|(2008)}} March of Dimes Prize in Developmental Biology {{small|(2018)}}}} |religion = |signature = |footnotes = }}Allan C. Spradling is an American scientist and principal investigator at the Carnegie Institution for Science and the Howard Hughes Medical Institute who studies egg development in the model organism, Drosophila melanogaster, a fruit fly.[2] He is considered a leading researcher in the developmental genetics of the fruit fly egg and has developed a number of techniques in his career that have led to greater understanding of fruit fly genetics including contributions to sequencing its genome.[2] He is also an adjunct professor at Johns Hopkins University and at the Johns Hopkins University School of Medicine.[2] EducationSpradling obtained an A.B. in physics from the University of Chicago and a Ph.D. in cell biology from the Massachusetts Institute of Technology.[2] CareerSpradling and American fellow American geneticist Gerald M. Rubin are considered pioneers in the field of genetics for their work in the early 1980s with their idea to "attach" a gene to a Drosophila transposon, P elements,[3] known to insert itself into fruit fly's chromosomes.[4] From this research came work from other scientists on transposons as a tool for genetic alterations in organisms.[4][5][6][7] In 2003 Spradling was awarded the Beadle Medal[1] and in 2008 Spradling was awarded the Gruber Prize in Genetics for his work on the Drosophila genome and continues his work in investigating novel technological approaches to genetics, egg development and stem cells. References1. ^1 {{Cite journal | last1 = Orr-Weaver | first1 = T. | title = The 2003 George W. Beadle Medal; Gerald M. Rubin and Allan C. Spradling | journal = Genetics | volume = 164 | issue = 4 | pages = 1248–1249 | year = 2003 | pmid = 15106662 | pmc = 1462668}} {{Authority control}}{{DEFAULTSORT:Spradling, Allan C.}}2. ^1 2 3 {{cite web|url=http://www.hhmi.org/research/investigators/spradling_bio.html |title=Howard Hughes Medical Institute Investigators: Allan C. Spradling, Ph.D. |accessdate=2009-10-25 }} 3. ^{{Cite journal | last1 = Spradling | first1 = A. | last2 = Rubin | first2 = G. | doi = 10.1126/science.6289435 | title = Transposition of cloned P elements into Drosophila germ line chromosomes | journal = Science | volume = 218 | issue = 4570 | pages = 341–347 | year = 1982 | pmid = 6289435| pmc = |bibcode = 1982Sci...218..341S }} 4. ^1 {{Cite book | last1 = Jedicke | first1 = Peter | title = Extreme science: transplanting your head and other feats of the future | year = 2001 | publisher = St. Martin's Griffin | location = New York | isbn = 978-0-312-26819-0 | pages = }} 5. ^{{Cite journal | last1 = Rubin | first1 = G. | last2 = Spradling | first2 = A. | title = Genetic transformation of Drosophila with transposable element vectors | journal = Science | volume = 218 | issue = 4570 | pages = 348–353 | year = 1982 | pmid = 6289436|bibcode = 1982Sci...218..348R |doi = 10.1126/science.6289436 }} 6. ^{{Cite journal | last1 = Spradling | first1 = A. | last2 = Drummond-Barbosa | first2 = D. | last3 = Kai | first3 = T. | title = Stem cells find their niche | journal = Nature | volume = 414 | issue = 6859 | pages = 98–104 | year = 2001 | doi = 10.1038/35102160 | pmid = 11689954 | pmc = |bibcode = 2001Natur.414...98S }} 7. ^{{Cite journal | last1 = Spradling | first1 = A. | last2 = Stern | first2 = D. | last3 = Beaton | first3 = A. | last4 = Rhem | first4 = E. | last5 = Laverty | first5 = T. | last6 = Mozden | first6 = N. | last7 = Misra | first7 = S. | last8 = Rubin | first8 = G. | title = The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes | journal = Genetics | volume = 153 | issue = 1 | pages = 135–177 | year = 1999 | pmid = 10471706 | pmc = 1460730}} 9 : Members of the United States National Academy of Sciences|Living people|American geneticists|University of Chicago alumni|Massachusetts Institute of Technology alumni|Johns Hopkins University faculty|Howard Hughes Medical Investigators|1949 births|Members of the American Philosophical Society |
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