| 词条 | Alpha-5 beta-1 |
| 释义 |
α5β1, also known as the fibronectin receptor[1], is an integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis.[2] It is composed of α5 (ITGA5/CD49e) and β1 (ITGB1/CD29) subunits. It is the primary receptor for fibronectin. The interaction of VLA-5 with fibronectin plays an important role in regulating inflammatory cytokine production by human articular chondrocytes (From the Cell Migration Gateway [https://web.archive.org/web/20110722014052/http://cmkb.cellmigration.org/report.cgi?report=compl_overview&compl_acc=cc00000020 ITGA5 ITGB1]). α5β1-integrin is transported inside the cell by the kinesin KIF1C,[3] a kinesin-3 organelle transporter that walks along microtubules. References1. ^Schaffner, F., Ray, A., & Dontenwill, M. (2013). Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors. Cancers, 5(4), 27-47. doi: 10.3390/cancers5010027 2. ^{{cite journal | author = Boudreau NJ, Varner JA | title = The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis | journal = J. Biol. Chem. | volume = 279 | issue = 6 | pages = 4862–8 |date=February 2004 | pmid = 14610084 | doi = 10.1074/jbc.M305190200 | url = | issn = }} 3. ^{{cite journal|last=Theisen|first=U|author2=Straube, E|author3= Straube, A|title=Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions.|journal=Developmental Cell|date=Dec 11, 2012|volume=23|issue=6|pages=1153–66|pmid=23237952|doi=10.1016/j.devcel.2012.11.005}} External links
1 : Integrins |
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