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词条 Alpha-L-fucosidase
释义

  1. Structural studies

  2. Human medical studies

  3. See also

  4. References

  5. Further reading

  6. External links

{{Infobox protein family
| Symbol = Alpha_L_fucos
| Name = Alpha-L-fucosidase
| image = PDB 1hl8 EBI.jpg
| width =
| caption = crystal structure of thermotoga maritima alpha-fucosidase
| Pfam = PF01120
| Pfam_clan = CL0058
| InterPro = IPR000933
| SMART =
| PROSITE = PDOC00324
| MEROPS =
| SCOP = 1hl9
| TCDB =
| OPM family =
| OPM protein =
| CAZy = GH29
| CDD =
}}{{enzyme
| Name = alpha-L-fucosidase
| EC_number = 3.2.1.51
| CAS_number = 9037-65-4
| IUBMB_EC_number = 3/2/1/51
| GO_code = 0004560
| image =
| width =
| caption =
}}

In enzymology, an alpha-L-fucosidase ({{EC number|3.2.1.51}}) is an enzyme that catalyzes the chemical reaction

an alpha-L-fucoside + H2O L-fucose + an alcohol

Thus, the two substrates of this enzyme are alpha-L-fucoside and H2O, whereas its two products are L-fucose and alcohol.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is alpha-L-fucoside fucohydrolase. This enzyme is also called alpha-fucosidase. This enzyme participates in n-glycan degradation and glycan structures - degradation.

Deficiency of this enzyme is called Fucosidosis.

In CAZy, alpha-L-fucosidases are found in glycoside hydrolase family 29 and glycoside hydrolase family 95.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1HL8}}, {{PDB link|1HL9}}, and {{PDB link|1ODU}}.

Human medical studies

It was in a recent study by Endreffy, Bjørklund and collaborators (2017) found an association between the activity of α-L-fucosidase-1 (FUCA-1) and chronic autoimmune disorders in children.[1] This should encourage further research on FUCA-1 as a marker of chronic inflammation and autoimmunity.

See also

  • 1,2-alpha-L-fucosidase
  • 1,3-alpha-L-fucosidase
  • 1,6-alpha-L-fucosidase
  • FUCA2

References

1. ^Endreffy I, Bjørklund G, Szerafin L, Urbina MA, Chirumbolo S, Endreffy E. Plasma alpha-L-fucosidase activity in chronic inflammation and autoimmune disorders in a pediatric cohort of hospitalized patients. Immunologic Research 2017. doi: 10.1007/s12026-017-8943-x.

Further reading

  • {{cite journal | vauthors = Levvy GA, Mcallan A | title = Mammalian fucosidases. 2. alpha-L-Fucosidase | journal = The Biochemical Journal | volume = 80 | issue = 2 | pages = 435–9 | date = August 1961 | pmid = 13761578 | pmc = 1244021 }}
  • {{cite journal | vauthors = Reglero A, Cabezas JA | title = Glycosidases of molluscs. Purification and properties of alpha-L-fucosidase from Chamelea gallina L | journal = European Journal of Biochemistry / FEBS | volume = 66 | issue = 2 | pages = 379–87 | date = July 1976 | pmid = 7458 | doi = 10.1111/j.1432-1033.1976.tb10527.x }}
  • {{cite journal | vauthors = Tanaka K, Nakano T, Noguchi S, Pigman W | title = Purification of alpha-L-fucosidase of abalone livers | journal = Archives of Biochemistry and Biophysics | volume = 126 | issue = 2 | pages = 624–33 | date = August 1968 | pmid = 5672520 | doi = 10.1016/0003-9861(68)90449-9 }}

External links

  • CAZy family GH29
  • CAZy family GH95
{{Sugar hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{3.2-enzyme-stub}}

3 : Protein families|EC 3.2.1|Enzymes of known structure
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