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词条 Alpha-taxilin
释义

  1. Gene

  2. References

  3. External links

  4. Further reading

{{Infobox_gene}}Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a protein that in humans is encoded by the TXLNA gene.[1][2][3]

Interleukin-14 is a cytokine that controls the growth and proliferation of both normal and cancerous B cells.[4] This molecule was also recently designated taxilin.[5] IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.

Gene

In murine models, two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β.[6] The il14 locus is near the gene for LCK on chromosome 1 in humans.

References

1. ^{{cite journal | vauthors = Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H | title = Identification and characterization of taxilin isoforms | journal = Biochem. Biophys. Res. Commun. | volume = 319 | issue = 3 | pages = 936–43 |date=Jun 2004 | pmid = 15184072 | pmc = | doi = 10.1016/j.bbrc.2004.05.073 }}
2. ^{{cite journal | vauthors = Nogami S, Satoh S, Nakano M, Terano A, Shirataki H | title = Interaction of taxilin with syntaxin which does not form the SNARE complex | journal = Biochem. Biophys. Res. Commun. | volume = 311 | issue = 4 | pages = 797–802 |date=Nov 2003 | pmid = 14623251 | pmc = | doi =10.1016/j.bbrc.2003.10.069 }}
3. ^{{cite web | title = Entrez Gene: TXLNA taxilin alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200081| accessdate = }}
4. ^{{cite journal | vauthors = Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ | title = Identification of a cDNA for a human high-molecular-weight B-cell growth factor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 90 | issue = 13 | pages = 6330–4 |date=July 1993 | pmid = 8327514 | pmc = 46922 | doi = 10.1073/pnas.90.13.6330}}
5. ^{{cite journal | vauthors = Nogami S, Satoh S, Nakano M, Shimizu H, Fukushima H, Maruyama A, Terano A, Shirataki H | title = Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells | journal = Genes Cells | volume = 8 | issue = 1 | pages = 17–28 |date=January 2003 | pmid = 12558796 | doi = 10.1046/j.1365-2443.2003.00612.x}}
6. ^{{cite journal | vauthors = Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL | title = Development of autoimmunity in IL-14alpha-transgenic mice | journal = J. Immunol. | volume = 177 | issue = 8 | pages = 5676–86 |date=October 2006 | pmid = 17015757 | doi = }}

External links

  • {{UCSC gene info|TXLNA}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors=Ambrus JL, Pippin J, Joseph A |title=Identification of a cDNA for a human high-molecular-weight B-cell growth factor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 13 |pages= 6330–4 |year= 1993 |pmid= 8327514 |doi=10.1073/pnas.90.13.6330 | pmc=46922 |display-authors=etal}}
  • {{cite journal | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
  • {{cite journal | vauthors=Ambrus JL, Pippin J, Joseph A |title=Identification of a cDNA for a human high molecular-weight B-cell growth factor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 15 |pages= 8154 |year= 1996 |pmid= 8755619 |doi= | pmc=38894 |display-authors=etal}}
  • {{cite journal | vauthors=Yu W, Andersson B, Worley KC |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |display-authors=etal}}
  • {{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
  • {{cite journal | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |display-authors=etal}}
  • {{cite journal | vauthors=Simpson JC, Wellenreuther R, Poustka A |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 |display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
  • {{cite journal | vauthors=Nogami S, Satoh S, Nakano M |title=Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells |journal=Genes Cells |volume=8 |issue= 1 |pages= 17–28 |year= 2003 |pmid= 12558796 |doi=10.1046/j.1365-2443.2003.00612.x |display-authors=etal}}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
  • {{cite journal | vauthors=Bouwmeester T, Bauch A, Ruffner H |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 |display-authors=etal}}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Wiemann S, Arlt D, Huber W |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |display-authors=etal}}
  • {{cite journal | vauthors=Mehrle A, Rosenfelder H, Schupp I |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |display-authors=etal}}
  • {{cite journal | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
  • {{cite journal | vauthors=Shen L, Zhang C, Wang T |title=Development of autoimmunity in IL-14alpha-transgenic mice |journal=J. Immunol. |volume=177 |issue= 8 |pages= 5676–86 |year= 2007 |pmid= 17015757 |doi= |display-authors=etal}}
  • {{cite journal | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
{{refend}}{{Interleukins}}{{Interleukin receptor modulators}}{{gene-1-stub}}

1 : Interleukins
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