| 词条 | Alternariol |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 443379918 | ImageFile=Alternariol.svg | ImageSize= | PIN=3,7,9-Trihydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one | OtherNames=3,7,9-Trihydroxy-1-methyl-6H-benzo[c]chromen-6-one |Section1={{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4514301 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = C16838 | InChI = 1/C14H10O5/c1-6-2-7(15)5-11-12(6)9-3-8(16)4-10(17)13(9)14(18)19-11/h2-5,15-17H,1H3 | InChIKey = CEBXXEKPIIDJHL-UHFFFAOYAX | SMILES1 = Cc1cc(cc2c1c3cc(cc(c3c(=O)o2)O)O)O | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 64983 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 519982 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C14H10O5/c1-6-2-7(15)5-11-12(6)9-3-8(16)4-10(17)13(9)14(18)19-11/h2-5,15-17H,1H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = CEBXXEKPIIDJHL-UHFFFAOYSA-N | CASNo_Ref = {{cascite|correct|??}} | CASNo=641-38-3 | PubChem=5359485 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = KN9L4260JW | SMILES=CC1=CC(=CC2=C1C3=CC(=CC(=C3C(=O)O2)O)O)O |Section2={{Chembox Properties | C=14 | H=10 | O=5 | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}Alternariol is a toxic metabolite of Alternaria fungi.[1] It is an important contaminant in cereals and fruits.[2] Alternariol exhibits antifungal and phytotoxic activity. It is reported to inhibit cholinesterase enzymes.[3] It is also a mycoestrogen. Alternariol is reported to be a full androgen agonist in an in vitro assay.[4] References1. ^{{cite journal |vauthors =Davis VM, Stack ME |title=Evaluation of alternariol and alternariol methyl ether for mutagenic activity in Salmonella typhimurium |journal=Appl. Environ. Microbiol. |volume=60 |issue=10 |pages=3901–2 |date=1 October 1994|pmid=7986060 |url=http://aem.asm.org/cgi/pmidlookup?view=long&pmid=7986060 |pmc=201908 }} {{Cholinergics}}{{Estrogenics}}{{organic-compound-stub}}2. ^{{cite journal |vauthors =Brugger EM, Wagner J, Schumacher DM |title=Mutagenicity of the mycotoxin alternariol in cultured mammalian cells |journal=Toxicol. Lett. |volume=164 |issue=3 |pages=221–30 |year=2006 |pmid=16464542 |doi=10.1016/j.toxlet.2006.01.001|display-authors=etal}} 3. ^Alternariol product page from Fermentek 4. ^{{cite journal|last1=Stypuła-Trębas|first1=Sylwia|last2=Minta|first2=Maria|last3=Radko|first3=Lidia|last4=Jedziniak|first4=Piotr|last5=Posyniak|first5=Andrzej|title=Nonsteroidal mycotoxin alternariol is a full androgen agonist in the yeast reporter androgen bioassay|journal=Environmental Toxicology and Pharmacology|volume=55|year=2017|pages=208–211|issn=13826689|doi=10.1016/j.etap.2017.08.036}} 6 : Mycotoxins|Natural phenols|Benzochromenes|Lactones|Resorcinols|Mycoestrogens |
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