| 词条 | AM-087 |
| 释义 |
| verifiedrevid = 477346628 | IUPAC_name = (6aR,10aR)-3-(2-methyl-6-bromohex-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol | image = AM-087.png | width = 240 | tradename = | legal_status = | routes_of_administration = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 152674-96-9 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 199561 | PubChem = 10717065 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 8892405 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C23H33BrO2/c1-15-8-9-18-17(12-15)21-19(25)13-16(14-20(21)26-23(18,4)5)22(2,3)10-6-7-11-24/h8,13-14,17-18,25H,6-7,9-12H2,1-5H3/t17-,18-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = RJPGJHLVEUSRRA-QZTJIDSGSA-N | C=23 | H=33 | Br=1 | O=2 | molecular_weight = 421.410 g/mol | smiles = CC3(C)C1CC=C(C)CC1c2c(O)cc(C(C)(C)CCCCBr)cc2O3 }}AM-087 (part of the AM cannabinoid series) is an analgesic drug which acts as a cannabinoid agonist.[1] It is a derivative of Δ8THC substituted on the 3-position side chain. AM-087 is a potent CB1 agonist with a Ki of 0.43nM, making it around 100x more potent than THC itself. This is most likely due to the bulky bromine substituent on the side chain.[2] See also
References1. ^{{cite journal|last1=Martin|first1=Billy R.|last2=Compton|first2=David R.|last3=Semus|first3=Simon F.|last4=Lin|first4=Sonyuan|last5=Marciniak|first5=Gilbert|last6=Grzybowska|first6=Jolanta|last7=Charalambous|first7=Avgui|authorlink8=Alexandros Makriyannis|last8=Makriyannis|first8=Alexandros|title=Pharmacological evaluation of iodo and nitro analogs of Δ8-THC and Δ9-THC|journal=Pharmacology Biochemistry and Behavior|volume=46|issue=2|year=1993|pages=295–301|issn=0091-3057|doi=10.1016/0091-3057(93)90356-X}} {{cannabinoids}}{{cannabinoid-stub}}2. ^Charalambous A, et al. Pharmacological evaluation of halogenated delta 8-THC analogs. Pharmacology Biochemistry and Behavior. 1991 Nov;40(3):509-12. {{PMID|1666915}} 5 : Cannabinoids|Benzochromenes|Phenols|Organobromides|AM cannabinoids |
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