| 词条 | AMG-1 |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477346872 | IUPAC_name = (6aR,10aR)-3-(hept-1-ynyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol | image = AMG-1.png | width = 240 | tradename = | legal_status = | routes_of_administration = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 205746-46-9 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 279147 | PubChem = 10830874 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 9006174 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C23H30O2/c1-5-6-7-8-9-10-17-14-20(24)22-18-13-16(2)11-12-19(18)23(3,4)25-21(22)15-17/h11,14-15,18-19,24H,5-8,12-13H2,1-4H3/t18-,19-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = PYCLMAJRHLLHNO-RTBURBONSA-N | C=23 | H=30 | O=2 | molecular_weight = 338.482 g/mol | smiles = CC=3CC1c2c(O)cc(C#CCCCCC)cc2OC(C)(C)C1CC=3 }}AMG-1 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC with a rigidified and extended 3-position side chain. AMG-1 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.6nM at CB1 vs 3.1nM at CB2.[1][2] See also
References1. ^{{cite journal|last1=Papahatjis|first1=Demetris P.|last2=Nikas|first2=Spyros P.|last3=Kourouli|first3=Therapia|last4=Chari|first4=Ravi|last5=Xu|first5=Wei|last6=Pertwee|first6=Roger G.|last7=Makriyannis|first7=Alexandros|authorlink7=Alexandros Makriyannis|title=Pharmacophoric Requirements for the Cannabinoid Side Chain. Probing the Cannabinoid Receptor Subsite at C1‘|journal=Journal of Medicinal Chemistry|volume=46|issue=15|year=2003|pages=3221–3229|issn=0022-2623|doi=10.1021/jm020558c|pmid=12852753}} {{cannabinoids}}{{cannabinoid-stub}}2. ^{{cite journal|last1=Keimowitz|first1=Alison R.|last2=Martin|first2=Billy R.|last3=Razdan|first3=Raj K.|last4=Crocker|first4=Peter J.|last5=Mascarella|first5=S. Wayne|last6=Thomas|first6=Brian F.|title=QSAR Analysis of Δ8-THC Analogues: Relationship of Side-Chain Conformation to Cannabinoid Receptor Affinity and Pharmacological Potency|journal=Journal of Medicinal Chemistry|volume=43|issue=1|year=2000|pages=59–70|issn=0022-2623|doi=10.1021/jm9902281}} 4 : Cannabinoids|Benzochromenes|Phenols|Alkynes |
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