| 词条 | AMG-41 |
| 释义 |
| verifiedrevid = 477236127 | IUPAC_name = (6aR,10aR)-3-(1-hexylcyclopropyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol | image = AMG-41.svg | width = 240 | tradename = | legal_status = | routes_of_administration = | metabolism = | elimination_half-life = | excretion = | CAS_number = 499237-35-3 | PubChem = 10361702 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 8537151 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 19847 | C=25 | H=36 | O=2 | molecular_weight = 368.551 g/mol | smiles = C=3CC2C(C)(C)Oc(cc(cc1O)C4(CC4)CCCCCC)c1C2CC=3C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C25H36O2/c1-5-6-7-8-11-25(12-13-25)18-15-21(26)23-19-14-17(2)9-10-20(19)24(3,4)27-22(23)16-18/h9,15-16,19-20,26H,5-8,10-14H2,1-4H3/t19-,20-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = UVQIBKXDOZWHFU-WOJBJXKFSA-N }}AMG-41 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with a cyclopropyl group on the C1'-position of the C3-alkyl side chain. AMG-41 is a potent agonist at both CB1 and CB2, with a Ki of 0.44 nM at CB1 vs 0.86 nM at CB2.[1][2][3] See also
References1. ^Papahatjis DP, Nikas SP, Andreou T, Makriyannis A. Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols. Bioorganic & Medicinal Chemistry Letters. 2002 Dec 16;12(24):3583-6. {{PMID|12443781}} {{cannabinoids}}{{cannabinoid-stub}}2. ^Papahatjis DP, et al. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. {{PMID|12852753}} 3. ^Papahatjis DP, et al. C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. Journal of Medicinal Chemistry. 2007 Aug 23;50(17):4048-60. {{PMID|17672444}} 3 : Cannabinoids|Benzochromenes|Phenols |
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