| 词条 | Ancylostoma braziliense |
| 释义 |
| image = Ancylostoma braziliense mouth parts CDC PHIL ID1375.jpg | image_caption = Ancylostoma braziliense, mouth parts | genus = Ancylostoma | species = braziliense | authority = Gomes de Faria 1910 }}Ancylostoma braziliense is a species of hookworm belonging to the genus Ancylostoma. It is an intestinal parasite of domestic cats and dogs. Severe infection is often fatal to these pets, especially in puppies and kittens. The infection is particularly endemic in the southern United States. It is most often confused with the zoonotic hookworm species Ancylostoma ceylanicum because of their uncanny resemblance.[1]A. braziliense larvae can cause accidental infection in humans called cutaneous larval migration or creeping eruption, which produces severe itching in the skin. It is the most common skin infection in tropical region, particularly along the beaches of the Caribbean.[2][3] Discovery and historyWhen A. braziliense was described by Gomes de Faria in 1910, and A. ceylanicum by Arthur Looss in 1911, the two species were regarded as synonymous because of their apparent similarities in almost all respect. Especially in 1913, comparison of specimens from human, dog, cat and lion infections in India led to the conclusion that they were definitely of the same species. In 1915 Gomes de Faria realised that the two were distinct species based on their anatomical structures. Till 1921 the two hookworms were accepted as a two valid species. However, in 1922 Gordon made an exhaustive comparison from specimens collected in Brazil, South Africa and India, and his conclusion was that there were no significant distinction. Other parasitologists were also convinced of this so that the two names were again considered synonymous. In 1951 Biocca made an elaborate study on different hookworms in the collection of London School of Hygiene and Tropical Medicine, the Liverpool School of Tropical Medicine and personal collections. He finally identified the defining characters between the two for classifying them as distinct species, which eventually gained general acceptance.[4] DistributionA. braziliense is endemic in the southern United States. It is also found in a number of subtropical regions around the world, including Central and South America, South Africa,[5] and southern Asia. In southern Asia, infection is confined to Indonesia, Borneo, and Malaysia.[1]Physical descriptionLike many other worms, the female worm is larger than the male. Also, the females are more difficult to distinguish because the teeth sizes appear very similar among the various species of Ancylostoma. Male worms, however, have two broad lateral lobes and a smaller dorsal lobe with rays on the copulatory bursa. These bursal rays' aids in distinguishing the different species of Ancylostoma.[6] Life cycleAncylostoma braziliense eggs are passed into the environment through the faeces of cats and dogs. The eggs incubate on warm, moist soil, where they hatch into larvae. The infective juvenile penetrate the skin of the host. At this stage, the larvae are present in the epidermis, hair follicles, and glands of the skin, sometimes extending to sebaceous glands where they form coils. Then they migrate to the heart and lung by moving along the blood circulation. In the lungs, the juveniles enter the alveoli and are propelled by cilia up the respiratory tract. From this, the host swallow them and deposit them in the small intestine. They get attached to the intestinal mucosa via the buccal capsule. Here they undergo two successive molts to become sexually mature individuals.[1]EtymologyHaving an etymology will definitely help in remembering the parasite. Etymology: Ancylo = curved + stoma = mouth; braziliense for the geographical location where the worms were first found.[7] Pathology{{Main|Cutaneous larva migrans}}It can cause "creeping eruption" or "ground itch".[8][9] It occurs when the larvae from the faeces of cats and dogs accidentally penetrate the human skin, causing severe itching and skin eruption. It is the most common ailment of tropically acquired dermatitis, particularly along the beaches of the Caribbean. However, humans are not the natural definitive hosts, and are therefore a dead-end for the parasites. In humans, the larvae die after few months without further development.[10] SymptomsAncylostoma braziliense is a parasite that infects cats and dogs and occasionally humans. And, they survive by eating blood from the intestine of cats and dogs, causing anemia. Pale gums and weakness are common signs of anemia. The infected animals also experience significant weight loss, bloody diarrhea, and are not able to grow up to their right size. Other symptoms like, skin irritation and itching is also caused by the larvae burrowing into the skin.[11] Diagnosis and treatmentA. braziliense is difficult to differentiate from other hookworms. Microscopic examination of scatological samples can identify the eggs as they are generally smaller than those of other species.[12]Most benzimidazoles are effective. Mebendazole, triclabendazole and fenbendazole are commonly used. Ivermectin and pyrantel pamoate are also effective. The combination of ivermectin 6 μg/kg and pyrantel pamoate at 5.0 mg/kg is 100% efficacious against adult worms in dogs.[13] Human infection in case of cutaneous larva migrans is treated with oral thiabendazole at 500 mg in 4 daily dose.[14] References1. ^1 2 {{cite web| author= Chapman S | title= Ancylostoma braziliense |url=http://animaldiversity.ummz.umich.edu/accounts/Ancylostoma_braziliense/ |year=2012 |work= Animal Diversity Web |publisher= Regents of the University of Michigan |accessdate=2013-06-30}} 2. ^{{cite journal|last1=Bowman|first1=Dwight D.|last2=Montgomery|first2=Susan P.|last3=Zajac|first3=Anne M.|last4=Eberhard|first4=Mark L.|last5=Kazacos|first5=Kevin R.|title=Hookworms of dogs and cats as agents of cutaneous larva migrans|journal=Trends in Parasitology|year=2010|volume=26|issue=4|pages=162–167|doi=10.1016/j.pt.2010.01.005|pmid=20189454}} 3. ^{{cite journal|last1=Feldmeier|first1=H.|last2=Schuster|first2=A.|title=Mini review: hookworm-related cutaneous larva migrans|journal= European Journal of Clinical Microbiology & Infectious Diseases |year=2012|volume=31|issue=6|pages=915–918|doi=10.1007/s10096-011-1404-x|pmid=21922198}} 4. ^{{cite journal| author= Yushida Y |title= Comparative studies on Ancylostoma braziliense and Ancylostoma ceylanicum. I. The adult stage |year =1971 | journal= The Journal of Parasitology | volume= 57 | issue=5 |pages = 983–989 |jstor= 3277850 | doi=10.2307/3277850}} 5. ^{{cite journal|last1=Minnaar|first1=W.N|last2=Krecek|first2=R.C|last3=Fourie|first3=L.J|title=Helminths in dogs from a peri-urban resource-limited community in Free State Province, South Africa|journal=Veterinary Parasitology|year=2002|volume=107|issue=4|pages=343–349|doi=10.1016/S0304-4017(02)00155-3|pmid=12163245}} 6. ^{{Cite web|url=http://animaldiversity.org/accounts/Ancylostoma_braziliense/|title=ADW: : INFORMATION|website=Animal Diversity Web|language=en|access-date=2018-04-26}} 7. ^{{Cite web|url=http://www.aavp.org/wiki/nematodes/strongylida/ancylostomatoidea/ancylostoma-braziliense/|title=Ancylostoma braziliense {{!}} American Association of Veterinary Parasitologists|website=www.aavp.org|language=en-US|access-date=2018-04-26}} 8. ^{{cite journal |vauthors=Shinkar RM, Stocks R, Thomas E |title=Cutaneous larva migrans, creeping eruption, sand worm |journal=Arch. Dis. Child. |volume=90 |issue=10 |pages=998 |year= 2005 |pmid=16177155 |pmc=1720113 |doi=10.1136/adc.2005.073197 |url=http://adc.bmj.com/cgi/pmidlookup?view=long&pmid=16177155}} 9. ^{{cite book |author1=Tierney, Lawrence M. |author2=McPhee, Stephen J. |author3=Papadakis, Maxine A. |title=Current medical diagnosis & treatment, 2008 |publisher=McGraw-Hill Medical |location= |year=2008 |page=1323 |isbn=0-07-149430-8 |accessdate=}} 10. ^{{cite journal|vauthors=Brenner MA, Patel MB |title= Cutaneous larva migrans: the creeping eruption |year =2003 | journal= Cutis | volume= 72 | issue= 2 |pages =111–115 |pmid= 12953933}} 11. ^{{Cite web|url=https://www.cdc.gov/dpdx/hookworm/index.html|title=CDC - DPDx - Hookworm|date=2017-12-13|website=www.cdc.gov|language=en-us|access-date=2018-04-26}} 12. ^{{cite journal|vauthors=Lucio-Forster A, Liotta JL, Yaros JP, Briggs KR, Mohammed HO, Bowman DD |title= Morphological differentiation of eggs of Ancylostoma caninum, Ancylostoma tubaeforme, and Ancylostoma braziliense from dogs and cats in the United States |year = 2012|url= | journal= J Parasitol | volume= 98 | issue= 5 |pages = 1041–1044 |pmid= 22394087 |doi=10.1645/GE-2928.1 }} 13. ^{{cite journal|vauthors=Shoop WL, Michael BF, Soll MD, Clark JN |title= Efficacy of an ivermectin and pyrantel pamoate combination against adult hookworm, Ancylostoma braziliense, in dogs |year = 1996|url= | journal= Aust Vet J | volume= 73 | issue= 3 |pages = 84–85 |pmid= 8660218 |doi= 10.1111/j.1751-0813.1996.tb09981.x}} 14. ^{{cite journal|vauthors=O'Quinn JC, Dushin R |title= Cutaneous larva migrans: case report with current recommendations for treatment |year = 2005| journal= J Am Podiatr Med Assoc | volume= 95 | issue= 3 |pages = 291–294 |pmid= 15901819 | doi=10.7547/0950291}} External links
3 : Parasitic diseases|Ancylostomatidae|Animals described in 1910 |
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