Andrew Bruce may refer to:

• Andrew Bruce (athlete) (born 1958), athlete from Trinidad and Tobago
• Andrew Davis Bruce (1894–1969), former Major General and President of the University of Houston
• Andy Bruce (born 1964), Scottish former professional football player
• Andrew A. Bruce (1866–1934), North Dakota Supreme Court justice
• Andrew Bruce (bishop) (died 1700), Scottish bishop
• Andrew Bruce, 11th Earl of Elgin (born 1924), Scottish nobleman
• Andrew William Bruce, sound designer and chairman of Autograph Sound

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