| 词条 | Androgen-dependent condition |
| 释义 |
An androgen-dependent condition, disease, disorder, or syndrome, is a medical condition that is, in part or full, dependent on, or is sensitive to, the presence of androgenic activity in the body. Known androgen-dependent conditions include acne,[1] seborrhea,[2][3][4] androgenic alopecia,[5] hirsutism,[6] hidradenitis suppurativa,[7] precocious puberty in boys,[8] hypersexuality,[9] paraphilias,[10] benign prostatic hyperplasia (BPH),[11] prostate cancer,[12] and hyperandrogenism in women such as in polycystic ovary syndrome (PCOS).[13][14] Such conditions may be treated with drugs with antiandrogen actions, including androgen receptor antagonists such as cyproterone acetate, spironolactone, and bicalutamide, 5α-reductase inhibitors such as finasteride and dutasteride, CYP17A1 inhibitors such as abiraterone acetate, gonadotropin-releasing hormone (GnRH) analogues such as leuprorelin and cetrorelix, and/or other antigonadotropins such as megestrol acetate and medroxyprogesterone acetate.[15][16] See also
References1. ^{{cite book|author1=Joseph E. Pizzorno|author2=Michael T. Murray|title=Textbook of Natural Medicine|url=https://books.google.com/books?id=6cjgo1IixvEC&pg=PA1157|year=2013|publisher=Elsevier Health Sciences|isbn=1-4377-2333-0|pages=1157–}} 2. ^{{cite book|author1=Steven B. Hoath|author2=Howard I. Maibach|title=Neonatal Skin: Structure and Function|url=https://books.google.com/books?id=KNQ9mY7ZkwUC&pg=PA67|date=18 April 2003|publisher=CRC Press|isbn=978-0-8247-0887-0|pages=67–}} 3. ^{{cite book|author1=Mariagrazia Stracquadanio|author2=Lilliana Ciotta|title=Metabolic Aspects of PCOS: Treatment With Insulin Sensitizers|url=https://books.google.com/books?id=w5xwCAAAQBAJ&pg=PA25|date=20 April 2015|publisher=Springer International Publishing|isbn=978-3-319-16760-2|pages=25–}} 4. ^{{cite book|author1=Krishna|author2=Usha R.|title=Adolescence|url=https://books.google.com/books?id=wPQ6LVIQaQQC&pg=PA124|date=1 March 2000|publisher=Orient Blackswan|isbn=978-81-250-1794-3|pages=124–}} 5. ^{{cite book|author1=Mark G. Lebwohl|author2=Warren R. Heymann|author3=John Berth-Jones|author4=Ian Coulson|title=Treatment of Skin Disease: Comprehensive Therapeutic Strategies|url=https://books.google.com/books?id=hRryAAAAQBAJ&pg=PA36|date=19 September 2013|publisher=Elsevier Health Sciences UK|isbn=978-0-7020-5236-1|pages=36–}} 6. ^{{cite book|author=Wilma F. Bergfeld|title=A Woman Doctor's Guide to Skin Care: Essential Facts and Information on Keeping Skin Healthy|url=https://books.google.com/books?id=zE9CjIgP7MYC|date=22 February 1996|publisher=Hyperion|isbn=978-0-7868-8100-0}} 7. ^{{cite book|author=Sarah Bekaert|title=Women's Health: A Practical Guide for Healthcare Professionals|url=https://books.google.com/books?id=1tWoLXYw9wsC&pg=PA128|year=2007|publisher=Radcliffe Publishing|isbn=978-1-84619-029-2|pages=128–}} 8. ^{{cite book|author1=Ora Hirsch Pescovitz|author2=Erica A. Eugster|title=Pediatric Endocrinology: Mechanisms, Manifestations, and Management|url=https://books.google.com/books?id=9gvBlktAT6YC&pg=PA328|year=2004|publisher=Lippincott Williams & Wilkins|isbn=978-0-7817-4059-3|pages=328–}} 9. ^{{cite book|title=Newsletter|url=https://books.google.com/books?id=HJtGAQAAIAAJ|year=1986|publisher=The Academy}} 10. ^{{cite book|author=Adrian Raine|title=Crime and Schizophrenia: Causes and Cures|url=https://books.google.com/books?id=3vy6kkygp9IC&pg=PA290|year=2006|publisher=Nova Publishers|isbn=978-1-59454-609-9|pages=290–}} 11. ^{{cite book|author1=Christopher R. Chapple|author2=William D. Steers|title=Practical Urology: Essential Principles and Practice: Essential Principles and Practice|url=https://books.google.com/books?id=A9m8TkdCUqEC&pg=PA361|date=10 May 2011|publisher=Springer Science & Business Media|isbn=978-1-84882-034-0|pages=361–}} 12. ^{{cite book|author=P. J. Bentley|title=Endocrine Pharmacology: Physiological Basis and Therapeutic Applications|url=https://books.google.com/books?id=W6M9AAAAIAAJ&pg=PA321|year=1980|publisher=CUP Archive|isbn=978-0-521-22673-8|pages=321–}} 13. ^{{cite book|author1=Raphael Rubin|author2=David S. Strayer|author3=Emanuel Rubin |author4=Jay M. McDonald |title=Rubin's Pathology: Clinicopathologic Foundations of Medicine|url=https://books.google.com/books?id=kD9VZ267wDEC&pg=PA816|year=2008|publisher=Lippincott Williams & Wilkins|isbn=978-0-7817-9516-6|pages=816–}} 14. ^{{cite book|author1=Andrea Dunaif|author2=R. Jeffrey Chang|author3=Stephen Franks|author4=Richard S. Legro|title=Polycystic Ovary Syndrome: Current Controversies, from the Ovary to the Pancreas|url=https://books.google.com/books?id=xdxqJuE7tSwC&pg=PA222|date=12 January 2008|publisher=Springer Science & Business Media|isbn=978-1-59745-108-6|pages=222–}} 15. ^{{cite book|author=Kenneth L. Becker|title=Principles and Practice of Endocrinology and Metabolism|url=https://books.google.com/books?id=FVfzRvaucq8C&pg=PA1195|year=2001|publisher=Lippincott Williams & Wilkins|isbn=978-0-7817-1750-2|pages=1195–}} 16. ^{{cite book|title=Annual Reports in Medicinal Chemistry|url=https://books.google.com/books?id=e2koZ5uWeaYC&pg=PA1994|date=3 October 1994|publisher=Academic Press|isbn=978-0-08-058373-0|pages=1994–}} Further reading
4 : Endocrine gonad disorders|Male genital disorders|Mammal reproductive system|Testosterone |
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