| 词条 | André Choulika | |||||||||||||||||||||
| 释义 |
| name = André Choulika | image = File:Andre Choulika portrait.jpg | image_size = | alt = | caption = | birth_date = | birth_place = | death_date = | death_place = | resting_place = | resting_place_coordinates = | residence = | citizenship = | nationality = | fields = Biology and Genetics | workplaces = Cellectis | alma_mater = Pierre and Marie Curie University, Institut Pasteur, Harvard Medical School, Boston Children's Hospital | doctoral_advisor = | academic_advisors =Bernard Dujon, Richard C. Mulligan, François Jacob, | doctoral_students = | notable_students = | known_for = genome editing technologies | author_abbrev_bot = | author_abbrev_zoo = | influences = | influenced = | awards = | signature = | signature_alt = | footnotes = | spouse = }}André Choulika (born 1965) is a biotechnologist, the inventor of nuclease-based genome editing and a pioneer in the analysis and use of meganucleases to modify complex genomes.[1][2][3] Early life and educationAndré Choulika was born in Beirut, Lebanon, in 1965, to a Russian father and Christian Lebanese mother. He left Lebanon in 1982, arriving in France via Nicosia, Cyprus.[4] After attending school in Nice, he went on to study biology and virology at Pierre and Marie Curie University (Paris VI),[4] where he joined Professor Bernard Dujon's lab. He earned his DEA degree at the Pasteur Institute in the laboratory of François Jacob, who was awarded the 1965 Nobel Prize in medicine and is considered to be the father of genetic research. While working with Jean-François Nicolas, Bernard Dujon and Arnaud Perrin in the early 1990s, Choulika was the first to use snipping nucleases (meganucleases) to edit genes in mammalian cells, giving rise to the modern field of gene editing.[5] After receiving his doctorate in molecular virology from Pierre and Marie Curie University-Paris VI, André completed a postdoctoral fellowship with Richard C. Mulligan at Harvard Medical School in the Department of Genetics. This work represented the first use of chimeric nucleases to edit genomes by homologous recombination. Later, while working in the Division of Molecular Medicine at Boston Children's Hospital, he developed the first approaches to meganuclease-based human gene therapy.[6] Innovation and entrepreneurshipIn 1999, Choulika founded the biopharmaceutical company Cellectis as a spin-off from the Pasteur Institute. The Pasteur Institute transferred licensing rights on nine patent families, including several based on his own research. Cellectis' work is focused on developing immunotherapies to target and eradicate cancers.[7] These are based on custom engineered CAR-T-cells (UCART), whose properties can be determined by genetic modification.[8] The company's mission is to develop a new generation of cancer therapies based on these engineered T-cells. Choulika has been a strong proponent of gene editing technologies as a concept that would survive the 21st century. In 2014, Cellectis entered into a collaboration with Pfizer to develop immunotherapies against selected targets in the field of oncology.[7] Cellectis also has research alliances with Weill Cornell Medical College and the MD Anderson Cancer Center at the University of Texas. An agricultural biotechnology subsidiary, Calyxt, Inc. (formerly Cellectis Plant Sciences, Inc.), was founded in 2010.[7] Its work includes the development of low-fat soybean oil and wheat with reduced gluten content.[4] André Choulika was a member of the Supervisory Board of Viroxis SA and was a member of the Investment Committee of G1J Ile-de-France. He was a Council member of ARIIS (the Health Industry Alliance for Research and Innovation), a board member for EuropaBio on emerging businesses, and a member of the scientific advisory program Biofutur. He was also the president of France Biotech (the French association of biotechnology companies) from 2009 to 2014. In 2013, he was appointed project manager of France's "medical biotechnology" program, one of 34 launched by Arnaud Montebourg, Minister of Industrial Renewal of France. Awards and recognition
Personal lifeAndré Choulika has three children.[4] He cites cycling, skiing and collecting modern art as hobbies.[4] Selected publications
Selected patents
References1. ^{{Cite news|url=http://labiotech.eu/cellectis-interview-car-t-is-not-the-cure-of-cancer/|title=Interview CEO of Cellectis: CAR-T is not the Cancer Cure-All|date=2015-11-30|work=Labiotech.eu|access-date=2017-12-25|language=en-US}} 2. ^{{Cite web|url=http://www.fiercebiotech.com/story/crucial-car-t-trial-looming-cellectis-confident-andr-choulika-laying-it-all/2015-06-02|title=With a crucial CAR-T trial looming for Cellectis, a confident André Choulika is laying it all on the line {{!}} FierceBiotech|website=www.fiercebiotech.com|language=en|access-date=2017-12-25}} 3. ^{{Cite web|url=https://www.nature.com/articles/nrd2432|title=Tools and technologies|date=2007-10-01|website=Nature Reviews Drug Discovery|language=En|access-date=2017-12-25}} 4. ^1 2 3 4 {{Cite web|url=https://www.liberation.fr/futurs/2018/04/17/andre-choulika-pas-gene_1644030|title=André Choulika, pas gêné|date=2018-04-17|website=Libération.fr|language=fr|access-date=2019-02-13}} 5. ^{{Cite journal|title = The yeast I-Sce I meganuclease induces site-directed chromosomal recombination in mammalian cells|journal = Comptes Rendus de l'Académie des Sciences, Série III|date = 1994-11-01|issn = 0764-4469|pmid = 7882137|pages = 1013–1019|volume = 317|issue = 11|first = A.|last = Choulika|first2 = A.|last2 = Perrin|first3 = B.|last3 = Dujon|first4 = J. F.|last4 = Nicolas}} 6. ^{{Cite web|url=https://www.weforum.org/people/andre-choulika/|title=André Choulika|website=World Economic Forum|access-date=2019-02-13}} 7. ^1 2 {{Cite web|url=https://www.cellectis.com/en/our-story|title=Our Story {{!}} Cellectis|website=www.cellectis.com|language=en|access-date=2019-02-13}} 8. ^{{Cite web|url = http://www.cellectis.com/en/research/immuno-oncology/|title = Cellectis - gene edited T-Cells|date = |accessdate = December 4, 2015|website = |publisher = |last = |first = }} 9. ^{{Cite web|url=http://biotechsmeawards.eu/previous-edition/2016-top-european-biotech-smes-announced-7th-edition-europabio-awards/|title=2016: Top European Biotech SMEs announced at 7th edition of EuropaBio Awards|website=Biotech SME Awards|language=en-US|access-date=2019-02-13}} 10. ^{{Cite web|url=https://www.technologyreview.com/lists/companies/2016/|title=50 Smartest Companies 2016|website=MIT Technology Review|language=en|access-date=2019-02-13}} 11. ^{{Cite journal|date=2002-10-01|title=I-SceI meganuclease mediates highly efficient transgenesis in fish|journal=Mechanisms of Development|volume=118|issue=1–2|pages=91–98|doi=10.1016/S0925-4773(02)00218-6|issn=0925-4773 | last1 = Thermes | first1 = Violette}} 12. ^{{Cite journal|date=1999-12-01|title=LagoZ et LagZ, deux gènes appauvris en dinucléotides CpG dérivés du gène LacZ pour l'étude des contrôles épigénétiques|journal=Comptes Rendus de l'Académie des Sciences, Série III|volume=322|issue=12|pages=1061–1070|doi=10.1016/S0764-4469(99)00105-5|issn=0764-4469 | last1 = Henry | first1 = Isabelle}} 13. ^{{Cite journal|last=Cohen-Tannoudji|first=M.|last2=Robine|first2=S.|last3=Choulika|first3=A.|last4=Pinto|first4=D.|last5=El Marjou|first5=F.|last6=Babinet|first6=C.|last7=Louvard|first7=D.|last8=Jaisser|first8=F.|date=March 1998|title=I-SceI-induced gene replacement at a natural locus in embryonic stem cells|journal=Molecular and Cellular Biology|volume=18|issue=3|pages=1444–1448|issn=0270-7306|pmid=9488460|doi=10.1128/mcb.18.3.1444|pmc=108858}} 14. ^{{Cite journal|last=Choulika|first=A.|last2=Perrin|first2=A.|last3=Dujon|first3=B.|last4=Nicolas|first4=J. F.|date=April 1995|title=Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae|journal=Molecular and Cellular Biology|volume=15|issue=4|pages=1968–1973|issn=0270-7306|pmid=7891691|doi=10.1128/mcb.15.4.1968|pmc=230423}} 15. ^1 2 3 4 5 {{cite web|title=Patents by Inventor Andre Choulika|url=https://patents.justia.com/inventor/andre-choulika|publisher=Justia Patents|accessdate=25 December 2017}} External links
4 : Living people|1965 births|French people of Lebanese descent|Lebanese chief executives |
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