| 词条 | Anisodamine |
| 释义 |
| Watchedfields = changed | verifiedrevid = 443393043 | IUPAC_name = [(1S,3S,5S,7S)-7-Hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2S)-3-hydroxy-2-phenyl-propanoate | image = Anisodamine.svg | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 55869-99-3 | ATC_prefix = None | ATC_suffix = | PubChem = 183088 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 159209 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 01343Q8EL8 | C=17 | H=23 | N=1 | O=4 | molecular_weight = 305.37 g/mol | smiles = O=C(O[C@@H]1C[C@@H]2N(C)[C@H](C1)C[C@@H]2O)[C@@H](c3ccccc3)CO | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C17H23NO4/c1-18-12-7-13(9-15(18)16(20)8-12)22-17(21)14(10-19)11-5-3-2-4-6-11/h2-6,12-16,19-20H,7-10H2,1H3/t12-,13+,14-,15+,16+/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = WTQYWNWRJNXDEG-LEOABGAYSA-N }}Anisodamine, also known as 7β-hydroxyhyoscyamine, is an anticholinergic and α1 adrenergic receptor antagonist used in the treatment of acute circulatory shock in China.[1] It is given orally or by injection, as a racemic mixture (racanisodamine) or as a hydrobromide salt.[2] Eye drops at 0.5% concentration for slowing the progression is also available in China.[3] Anisodamine is a naturally occurring tropane alkaloid found in some plants of the Solanaceae family.[4] Its Mandarin Chinese name {{lang|zh-Hans-CN|山莨菪碱}} is given after Anisodus tanguticus ({{zh|t=山莨菪|p=shān làng dàng}}).[5] See also
References1. ^{{cite journal | vauthors = Varma DR, Yue TL | title = Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of rats | journal = British Journal of Pharmacology | volume = 87 | issue = 3 | pages = 587–94 |date=March 1986 | pmid = 2879586 | pmc = 1916562 | doi = 10.1111/j.1476-5381.1986.tb10201.x| url = }} {{Adrenergic receptor modulators}}{{Muscarinic acetylcholine receptor modulators}}{{cardiovascular-drug-stub}}2. ^{{cite web|title=Pharmacopoeia Search: "山莨菪碱"|url=http://www.yaobiaozhun.com/yd2015/index.php?k=%E5%B1%B1%E8%8E%A8%E8%8F%AA%E7%A2%B1|publisher=中国药典}} 3. ^{{cite journal|title=消旋山莨菪碱滴眼液防治少年儿童假性近视的疗效分析|journal=国际医药卫生导报|date=2008|volume=14|issue=15|pages=67–68|doi=10.3760/cma.j.issn.1007-1245.2008.15.027|url=http://med.wanfangdata.com.cn/Paper/Detail?id=PeriodicalPaper_gjyywsdb200815027|language=zh-cn}} 4. ^{{cite journal | vauthors = Zhang WW, Song MK, Cui YY | title = Differential neuropsychopharmacological influences of naturally occurring tropane alkaloids anisodamine versus scopolamine | journal = Neuroscience Letters | volume = 443 | issue = 3 | pages = 241–5 |date=October 2008 | pmid = 18672024 | doi = 10.1016/j.neulet.2008.07.048 | url = http://linkinghub.elsevier.com/retrieve/pii/S0304-3940(08)01006-9|display-authors=etal}} 5. ^{{cite web|title=消旋山莨菪碱|url=http://www.yaobiaozhun.com/yd2015/view.php?v=txt&id=4045|publisher=中国药典|accessdate=3 December 2017|archiveurl=https://archive.fo/xz2PX|archivedate=2017-12-03|language=zh-CN}} 4 : Alpha-adrenergic agonists|Muscarinic antagonists|Tropane alkaloids|Tropane alkaloids found in Solanaceae |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。