| 释义 |
- Function
- See also
- References
- Further reading
{{Infobox_gene}}Acidic leucine-rich nuclear phosphoprotein 32 family member C is a protein that in humans is encoded by the ANP32C gene.[1][2][3] Function Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns.[3] See also - ANP32A, ANP32B, ANP32D, ANP32E
References 1. ^{{cite journal | vauthors = Kadkol SS, Brody JR, Pevsner J, Bai J, Pasternack GR | title = Modulation of oncogenic potential by alternative gene use in human prostate cancer | journal = Nature Medicine | volume = 5 | issue = 3 | pages = 275–9 | date = March 1999 | pmid = 10086381 | pmc = | doi = 10.1038/6488 }}
2. ^{{cite journal | vauthors = Brody JR, Kadkol SS, Mahmoud MA, Rebel JM, Pasternack GR | title = Identification of sequences required for inhibition of oncogene-mediated transformation by pp32 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 29 | pages = 20053–5 | date = July 1999 | pmid = 10400610 | pmc = | doi = 10.1074/jbc.274.29.20053 }}
3. ^1 {{cite web | title = Entrez Gene: ANP32C acidic (leucine-rich) nuclear phosphoprotein 32 family, member C| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23520| accessdate = }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Matilla A, Radrizzani M | title = The Anp32 family of proteins containing leucine-rich repeats | journal = Cerebellum | volume = 4 | issue = 1 | pages = 7–18 | year = 2005 | pmid = 15895553 | doi = 10.1080/14734220410019020 }}
- {{cite journal | vauthors = Kochevar GJ, Brody JR, Kadkol SS, Murphy KM, Pasternack GR | title = Identification of a functional mutation in pp32r1 (ANP32C) | journal = Human Mutation | volume = 23 | issue = 6 | pages = 546–51 | date = June 2004 | pmid = 15146458 | doi = 10.1002/humu.20030 }}
- {{cite journal | vauthors = Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J | title = Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A | journal = Nature Immunology | volume = 4 | issue = 2 | pages = 145–53 | date = February 2003 | pmid = 12524539 | doi = 10.1038/ni885 }}
- {{cite journal | vauthors = Kadkol SS, El Naga GA, Brody JR, Bai J, Gusev Y, Dooley WC, Pasternack GR | title = Expression of pp32 gene family members in breast cancer | journal = Breast Cancer Research and Treatment | volume = 68 | issue = 1 | pages = 65–73 | date = July 2001 | pmid = 11678310 | doi = 10.1023/A:1017919507109 }}
- {{cite journal | vauthors = Bai J, Brody JR, Kadkol SS, Pasternack GR | title = Tumor suppression and potentiation by manipulation of pp32 expression | journal = Oncogene | volume = 20 | issue = 17 | pages = 2153–60 | date = April 2001 | pmid = 11360199 | doi = 10.1038/sj.onc.1204294 }}
- {{cite journal | vauthors = Kadkol SS, Brody JR, Pevsner J, Bai J, Pasternack GR | title = Correction to "Modulation of oncogenic potential by alternative gene use in human prostate cancer" | journal = Nature Medicine | volume = 5 | issue = 9 | pages = 1087 | date = September 1999 | pmid = 10471270 | doi = 10.1038/12530 }}
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