| 释义 |
- See also
- References
- External links
- Further reading
{{Infobox_gene}}Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32E gene.[1][2] The ANP32E gene is located on chromosome 1q22.[1] In mammalian cells, ANP32E has been shown to be an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin.[3] In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis[4] and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.[5]See also- ANP32A, ANP32B, ANP32C, ANP32D
References1. ^1 {{cite journal |vauthors=Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, Tang R, Xie Y, Mao Y | title = Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain | journal = Cytogenet Genome Res | volume = 97 | issue = 1–2 | pages = 68–71 |date=Nov 2002 | pmid = 12438741 | pmc = | doi =10.1159/000064058 }}
2. ^{{cite web | title = Entrez Gene: ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81611| accessdate = }}
3. ^{{cite journal |vauthors=Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A | title = ANP32E is a histone chaperone that removes H2A.Z from chromatin | journal = Nature | volume = 505 | issue = 7485 | pages = 648–53 | year = 2014 | pmid = 24463511 | doi = 10.1038/nature12922 }}
4. ^{{cite journal |vauthors=Costanzo RV, Vilá-Ortíz GJ, Perandones C, Carminatti H, Matilla A, Radrizzani M | title = Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis | journal = Eur. J. Neurosci. | volume = 23 | issue = 2 | pages = 309–24 | year = 2006 | pmid = 16420440 | doi = 10.1111/j.1460-9568.2005.04555.x }}
5. ^{{cite journal | author = Santa-Coloma TA | title = Anp32e (Cpd1) and related protein phosphatase 2 inhibitors | journal = Cerebellum | volume = 2 | issue = 4 | pages = 310–20 | year = 2003 | pmid = 14964690 | doi = 10.1080/14734220310017212 }}
External links- {{UCSC gene info|ANP32E}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Matilla A, Radrizzani M |title=The Anp32 family of proteins containing leucine-rich repeats |journal=Cerebellum |volume=4 |issue= 1 |pages= 7–18 |year= 2005 |pmid= 15895553 |doi=10.1080/14734220410019020 }}
- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
- {{cite journal |vauthors=Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | year = 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
{{refend}}{{gene-1-stub}} |