| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene.[1]This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.[1] References1. ^1 {{cite web | title = Entrez Gene: ANXA8 annexin A8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=244| accessdate = }}
External links- {{UCSC gene info|ANXA8}}
- {{UCSC gene info|ANXA8L1}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Gerke V, Moss SE |title=Annexins: from structure to function. |journal=Physiol. Rev. |volume=82 |issue= 2 |pages= 331–71 |year= 2002 |pmid= 11917092 |doi= 10.1152/physrev.00030.2001 }}
- {{cite journal |vauthors=Gerke V, Creutz CE, Moss SE |title=Annexins: linking Ca2+ signaling to membrane dynamics. |journal=Nat. Rev. Mol. Cell Biol. |volume=6 |issue= 6 |pages= 449–61 |year= 2005 |pmid= 15928709 |doi= 10.1038/nrm1661 }}
- {{cite journal |vauthors=Chang KS, Wang G, Freireich EJ |title=Specific expression of the annexin VIII gene in acute promyelocytic leukemia. |journal=Blood |volume=79 |issue= 7 |pages= 1802–10 |year= 1992 |pmid= 1313714 |doi= |display-authors=etal}}
- {{cite journal |vauthors=Chambers JA, Gardner E, Hauptmann R |title=TaqI polymorphisms at the annexin VIII locus (ANX8). |journal=Hum. Mol. Genet. |volume=1 |issue= 7 |pages= 550 |year= 1993 |pmid= 1364010 |doi=10.1093/hmg/1.7.550 |display-authors=etal}}
- {{cite journal |vauthors=Hauptmann R, Maurer-Fogy I, Krystek E |title=Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha. |journal=Eur. J. Biochem. |volume=185 |issue= 1 |pages= 63–71 |year= 1989 |pmid= 2530088 |doi=10.1111/j.1432-1033.1989.tb15082.x |display-authors=etal}}
- {{cite journal |vauthors=Sarkar A, Yang P, Fan YH |title=Regulation of the expression of annexin VIII in acute promyelocytic leukemia. |journal=Blood |volume=84 |issue= 1 |pages= 279–86 |year= 1994 |pmid= 8018923 |doi= |display-authors=etal}}
- {{cite journal |vauthors=Reutelingsperger CP, van Heerde W, Hauptmann R |title=Differential tissue expression of Annexin VIII in human. |journal=FEBS Lett. |volume=349 |issue= 1 |pages= 120–4 |year= 1994 |pmid= 8045287 |doi=10.1016/0014-5793(94)00559-1 |display-authors=etal}}
- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal |vauthors=Deloukas P, Earthrowl ME, Grafham DV |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |display-authors=etal}}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal |vauthors=Stein T, Price KN, Morris JS |title=Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer. |journal=Clin. Cancer Res. |volume=11 |issue= 19 Pt 1 |pages= 6872–9 |year= 2006 |pmid= 16203777 |doi= 10.1158/1078-0432.CCR-05-0547 |display-authors=etal}}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
- {{cite journal |vauthors=Goebeler V, Ruhe D, Gerke V, Rescher U |title=Annexin A8 displays unique phospholipid and F-actin binding properties. |journal=FEBS Lett. |volume=580 |issue= 10 |pages= 2430–4 |year= 2006 |pmid= 16638567 |doi= 10.1016/j.febslet.2006.03.076 }}
{{refend}}{{PDB Gallery|geneid=244}}{{protein-stub}} |