Anzai (written: 安西, 安斎 or 安済) is a Japanese surname. Notable people with the surname include:

• {{Nihongo|Atsuko Anzai|安西 篤子||born 1927}}, Japanese novelist
• {{Nihongo|Chika Anzai|安済 知佳||born 1990}}, Japanese voice actress
• Earl I. Anzai (born 1941), American lawyer and politician
• Emma Anzai, Australian musician
• {{Nihongo|Hiroko Anzai|安西 ひろこ||born 1979}}, Japanese actress, model and gravure idol
• {{Nihongo|Fuyue Anzai|安西 冬衛||1898–1965}}, Japanese poet
• {{Nihongo|Nobuaki Anzai|安斎 伸彰||born 1985}}, Japanese Go player
• {{Nihongo|Nobuyuki Anzai|安西 信行||born 1972}}, Japanese manga artist
• {{Nihongo|Shigeo Anzai|安斎 重男 ||born 1939}}, Japanese photographer

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