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词条 APBA1
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

  5. External links

{{Infobox_gene}}Amyloid beta A4 precursor protein-binding family A member 1 is a protein that in humans is encoded by the APBA1 gene.[1][2][3]

Function

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.[3]

Interactions

APBA1 has been shown to interact with KCNJ12,[4][5] CCS,[6] CASK[7][8] and Amyloid precursor protein.[9][10]

References

1. ^{{cite journal | vauthors = Duclos F, Boschert U, Sirugo G, Mandel JL, Hen R, Koenig M | title = Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 1 | pages = 109–13 | date = February 1993 | pmid = 7678331 | pmc = 45609 | doi = 10.1073/pnas.90.1.109 }}
2. ^{{cite journal | vauthors = Duclos F, Koenig M | title = Comparison of primary structure of a neuron-specific protein, X11, between human and mouse | journal = Mamm Genome | volume = 6 | issue = 1 | pages = 57–8 | date = May 1995 | pmid = 7719031 | pmc = | doi = 10.1007/BF00350899 }}
3. ^1 {{cite web | title = Entrez Gene: APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=320| accessdate = }}
4. ^{{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 22331–46 | date = May 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 }}
5. ^{{cite journal | vauthors = Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA | title = A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels | journal = J. Biol. Chem. | volume = 279 | issue = 18 | pages = 19051–63 | date = April 2004 | pmid = 14960569 | doi = 10.1074/jbc.M400284200 }}
6. ^{{cite journal | vauthors = McLoughlin DM, Standen CL, Lau KF, Ackerley S, Bartnikas TP, Gitlin JD, Miller CC | title = The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity | journal = J. Biol. Chem. | volume = 276 | issue = 12 | pages = 9303–7 | date = March 2001 | pmid = 11115513 | doi = 10.1074/jbc.M010023200 }}
7. ^{{cite journal | vauthors = Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B | title = Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting | journal = J. Biol. Chem. | volume = 273 | issue = 48 | pages = 31633–6 | date = November 1998 | pmid = 9822620 | doi = 10.1074/jbc.273.48.31633 }}
8. ^{{cite journal | vauthors = Borg JP, Lõpez-Figueroa MO, de Taddèo-Borg M, Kroon DE, Turner RS, Watson SJ, Margolis B | title = Molecular analysis of the X11-mLin-2/CASK complex in brain | journal = J. Neurosci. | volume = 19 | issue = 4 | pages = 1307–16 | date = February 1999 | pmid = 9952408 }}
9. ^{{cite journal | vauthors = Biederer T, Cao X, Südhof TC, Liu X | title = Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms | journal = J. Neurosci. | volume = 22 | issue = 17 | pages = 7340–51 | date = September 2002 | pmid = 12196555 }}
10. ^{{cite journal | vauthors = Borg JP, Ooi J, Levy E, Margolis B | title = The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein | journal = Mol. Cell. Biol. | volume = 16 | issue = 11 | pages = 6229–41 | date = November 1996 | pmid = 8887653 | pmc = 231626 | doi=10.1128/mcb.16.11.6229}}

Further reading

{{Refbegin | 2}}
  • {{cite journal | vauthors = van der Geer P, Pawson T | title = The PTB domain: a new protein module implicated in signal transduction. | journal = Trends Biochem. Sci. | volume = 20 | issue = 7 | pages = 277–80 | year = 1995 | pmid = 7545337 | doi = 10.1016/S0968-0004(00)89043-X }}
  • {{cite journal | vauthors = Chen WJ, Goldstein JL, Brown MS | title = NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. | journal = J. Biol. Chem. | volume = 265 | issue = 6 | pages = 3116–23 | year = 1990 | pmid = 1968060 | doi = }}
  • {{cite journal | vauthors = Borg JP, Ooi J, Levy E, Margolis B | title = The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. | journal = Mol. Cell. Biol. | volume = 16 | issue = 11 | pages = 6229–41 | year = 1996 | pmid = 8887653 | pmc = 231626 | doi = 10.1128/mcb.16.11.6229}}
  • {{cite journal | vauthors = Zhang Z, Lee CH, Mandiyan V, Borg JP, Margolis B, Schlessinger J, Kuriyan J | title = Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. | journal = EMBO J. | volume = 16 | issue = 20 | pages = 6141–50 | year = 1997 | pmid = 9321393 | pmc = 1326298 | doi = 10.1093/emboj/16.20.6141 }}
  • {{cite journal | vauthors = Okamoto M, Südhof TC | title = Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. | journal = J. Biol. Chem. | volume = 272 | issue = 50 | pages = 31459–64 | year = 1998 | pmid = 9395480 | doi = 10.1074/jbc.272.50.31459 }}
  • {{cite journal | vauthors = Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM | title = Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein. | journal = Mamm. Genome | volume = 9 | issue = 6 | pages = 473–5 | year = 1998 | pmid = 9585438 | doi = 10.1007/s003359900800 }}
  • {{cite journal | vauthors = Borg JP, Yang Y, De Taddéo-Borg M, Margolis B, Turner RS | title = The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion. | journal = J. Biol. Chem. | volume = 273 | issue = 24 | pages = 14761–6 | year = 1998 | pmid = 9614075 | doi = 10.1074/jbc.273.24.14761 }}
  • {{cite journal | vauthors = Butz S, Okamoto M, Südhof TC | title = A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. | journal = Cell | volume = 94 | issue = 6 | pages = 773–82 | year = 1998 | pmid = 9753324 | doi = 10.1016/S0092-8674(00)81736-5 }}
  • {{cite journal | vauthors = Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B | title = Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. | journal = J. Biol. Chem. | volume = 273 | issue = 48 | pages = 31633–6 | year = 1998 | pmid = 9822620 | doi = 10.1074/jbc.273.48.31633 }}
  • {{cite journal | vauthors = Borg JP, Lõpez-Figueroa MO, de Taddèo-Borg M, Kroon DE, Turner RS, Watson SJ, Margolis B | title = Molecular analysis of the X11-mLin-2/CASK complex in brain. | journal = J. Neurosci. | volume = 19 | issue = 4 | pages = 1307–16 | year = 1999 | pmid = 9952408 | doi = }}
  • {{cite journal | vauthors = Maximov A, Südhof TC, Bezprozvanny I | title = Association of neuronal calcium channels with modular adaptor proteins. | journal = J. Biol. Chem. | volume = 274 | issue = 35 | pages = 24453–6 | year = 1999 | pmid = 10455105 | doi = 10.1074/jbc.274.35.24453 }}
  • {{cite journal | vauthors = Mueller HT, Borg JP, Margolis B, Turner RS | title = Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains. | journal = J. Biol. Chem. | volume = 275 | issue = 50 | pages = 39302–6 | year = 2001 | pmid = 11010978 | doi = 10.1074/jbc.M008453200 }}
  • {{cite journal | vauthors = Biederer T, Südhof TC | title = Mints as adaptors. Direct binding to neurexins and recruitment of munc18. | journal = J. Biol. Chem. | volume = 275 | issue = 51 | pages = 39803–6 | year = 2001 | pmid = 11036064 | doi = 10.1074/jbc.C000656200 }}
  • {{cite journal | vauthors = Lau KF, McLoughlin DM, Standen C, Miller CC | title = X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains. | journal = Mol. Cell. Neurosci. | volume = 16 | issue = 5 | pages = 557–65 | year = 2001 | pmid = 11083918 | doi = 10.1006/mcne.2000.0898 }}
  • {{cite journal | vauthors = McLoughlin DM, Standen CL, Lau KF, Ackerley S, Bartnikas TP, Gitlin JD, Miller CC | title = The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity. | journal = J. Biol. Chem. | volume = 276 | issue = 12 | pages = 9303–7 | year = 2001 | pmid = 11115513 | doi = 10.1074/jbc.M010023200 }}
  • {{cite journal | vauthors = Bécamel C, Alonso G, Galéotti N, Demey E, Jouin P, Ullmer C, Dumuis A, Bockaert J, Marin P | title = Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach. | journal = EMBO J. | volume = 21 | issue = 10 | pages = 2332–42 | year = 2002 | pmid = 12006486 | pmc = 126011 | doi = 10.1093/emboj/21.10.2332 }}
  • {{cite journal | vauthors = Ho CS, Marinescu V, Steinhilb ML, Gaut JR, Turner RS, Stuenkel EL | title = Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism. | journal = J. Biol. Chem. | volume = 277 | issue = 30 | pages = 27021–8 | year = 2002 | pmid = 12016213 | doi = 10.1074/jbc.M201823200 }}
{{Refend}}

External links

  • {{UCSC gene info|APBA1}}
{{PDB Gallery|geneid=320}}{{Gene-9-stub}}
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