| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.[1][2]The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.[2] References1. ^{{cite journal |vauthors=Lee DS, Tomita S, Kirino Y, Suzuki T | title = Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein | journal = J Biol Chem | volume = 275 | issue = 30 | pages = 23134–8 |date=Aug 2000 | pmid = 10833507 | pmc = | doi = 10.1074/jbc.C000302200 }}
2. ^1 {{cite web | title = Entrez Gene: APBA2BP amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63941| accessdate = }}
External links- {{UCSC gene info|NECAB3}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Büssow K, Cahill D, Nietfeld W |title=A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. |journal=Nucleic Acids Res. |volume=26 |issue= 21 |pages= 5007–8 |year= 1998 |pmid= 9776767 |doi=10.1093/nar/26.21.5007 | pmc=147919 |display-authors=etal}}
- {{cite journal |vauthors=Sugita S, Südhof TC |title=Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins. |journal=Biochemistry |volume=39 |issue= 11 |pages= 2940–9 |year= 2000 |pmid= 10715114 |doi=10.1021/bi9920984 }}
- {{cite journal |vauthors=Deloukas P, Matthews LH, Ashurst J |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |display-authors=etal}}
- {{cite journal |vauthors=Sugita S, Ho A, Südhof TC |title=NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. |journal=Neuroscience |volume=112 |issue= 1 |pages= 51–63 |year= 2002 |pmid= 12044471 |doi=10.1016/S0306-4522(02)00063-5 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal |vauthors=Sumioka A, Imoto S, Martins RN |title=XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. |journal=Biochem. J. |volume=374 |issue= Pt 1 |pages= 261–8 |year= 2003 |pmid= 12780348 |doi= 10.1042/BJ20030489 | pmc=1223589 |display-authors=etal}}
- {{cite journal |vauthors=Yoo JC, Chang JR, Kim SH |title=NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi. |journal=Exp. Cell Res. |volume=292 |issue= 2 |pages= 393–402 |year= 2004 |pmid= 14697346 |doi=10.1016/j.yexcr.2003.09.025 |display-authors=etal}}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
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