| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}Amyloid beta A4 precursor protein-binding family B member 2 is a protein that in humans is encoded by the APBB2 gene.[1][2][3]The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction.[3] References1. ^{{cite journal |vauthors=McLoughlin DM, Miller CC | title = The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system | journal = FEBS Lett | volume = 397 | issue = 2–3 | pages = 197–200 |date=Jan 1997 | pmid = 8955346 | pmc = | doi =10.1016/S0014-5793(96)01128-3 }}
2. ^{{cite journal |vauthors=Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM | title = Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein | journal = Mamm Genome | volume = 9 | issue = 6 | pages = 473–5 |date=Jun 1998 | pmid = 9585438 | pmc = | doi = 10.1007/s003359900800}}
3. ^1 {{cite web | title = Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=323| accessdate = }}
External linksFurther reading{{refbegin | 2}}- {{cite journal |vauthors=Guénette SY, Chen J, Jondro PD, Tanzi RE |title=Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 20 |pages= 10832–7 |year= 1996 |pmid= 8855266 |doi=10.1073/pnas.93.20.10832 | pmc=38241 }}
- {{cite journal |vauthors=Bruni P, Minopoli G, Brancaccio T |title=Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35481–8 |year= 2002 |pmid= 12089154 |doi= 10.1074/jbc.M205227200 |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal |vauthors=Chang Y, Tesco G, Jeong WJ |title=Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1 |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51100–7 |year= 2004 |pmid= 14527950 |doi= 10.1074/jbc.M309561200 |display-authors=etal}}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal |vauthors=Li Y, Hollingworth P, Moore P |title=Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease |journal=Hum. Mutat. |volume=25 |issue= 3 |pages= 270–7 |year= 2006 |pmid= 15714520 |doi= 10.1002/humu.20138 |display-authors=etal}}
- {{cite journal |vauthors=Lange A, Thon L, Mathieu S, Adam D |title=The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor |journal=Biochem. Biophys. Res. Commun. |volume=335 |issue= 2 |pages= 575–83 |year= 2005 |pmid= 16083851 |doi= 10.1016/j.bbrc.2005.07.125 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
- {{cite journal |vauthors=Hong Q, Hsu LJ, Schultz L |title=Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-κB, JNK1, p53 and WOX1 during stress response |journal=BMC Mol. Biol. |volume=8|pages= 50 |year= 2007 |pmid= 17567906 |doi= 10.1186/1471-2199-8-50 | pmc=1904229 |display-authors=etal}}
{{refend}}{{PDB Gallery|geneid=323}}{{gene-4-stub}} |