| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}DNA dC->dU-editing enzyme APOBEC-3F is a protein that in humans is encoded by the APOBEC3F gene.[1][2][3]This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified.[3] References1. ^{{cite journal |vauthors=Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N | title = An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22 | journal = Genomics | volume = 79 | issue = 3 | pages = 285–96 |date=Feb 2002 | pmid = 11863358 | pmc = | doi = 10.1006/geno.2002.6718 }}
2. ^{{cite journal |vauthors=Holmes RK, Koning FA, Bishop KN, Malim MH | title = APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G | journal = J Biol Chem | volume = 282 | issue = 4 | pages = 2587–95 |date=Jan 2007 | pmid = 17121840 | pmc = | doi = 10.1074/jbc.M607298200 }}
3. ^1 {{cite web | title = Entrez Gene: APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200316| accessdate = }}
External links- {{UCSC gene info|APOBEC3F}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Wedekind JE, Dance GS, Sowden MP, Smith HC |title=Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business. |journal=Trends Genet. |volume=19 |issue= 4 |pages= 207–16 |year= 2003 |pmid= 12683974 |doi=10.1016/S0168-9525(03)00054-4 }}
- {{cite journal |vauthors=Franca R, Spadari S, Maga G |title=APOBEC deaminases as cellular antiviral factors: a novel natural host defense mechanism. |journal=Med. Sci. Monit. |volume=12 |issue= 5 |pages= RA92–8 |year= 2006 |pmid= 16641889 |doi= }}
- {{cite journal |vauthors=Prashar Y, Weissman SM |title=Analysis of differential gene expression by display of 3' end restriction fragments of cDNAs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 2 |pages= 659–63 |year= 1996 |pmid= 8570611 |doi=10.1073/pnas.93.2.659 | pmc=40108 }}
- {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
- {{cite journal |vauthors=Dunham I, Shimizu N, Roe BA |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal |vauthors=Zheng YH, Irwin D, Kurosu T |title=Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication. |journal=J. Virol. |volume=78 |issue= 11 |pages= 6073–6 |year= 2004 |pmid= 15141007 |doi= 10.1128/JVI.78.11.6073-6076.2004 | pmc=415831 |display-authors=etal}}
- {{cite journal |vauthors=Wiegand HL, Doehle BP, Bogerd HP, Cullen BR |title=A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins. |journal=EMBO J. |volume=23 |issue= 12 |pages= 2451–8 |year= 2004 |pmid= 15152192 |doi= 10.1038/sj.emboj.7600246 | pmc=423288 }}
- {{cite journal |vauthors=Liddament MT, Brown WL, Schumacher AJ, Harris RS |title=APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo. |journal=Curr. Biol. |volume=14 |issue= 15 |pages= 1385–91 |year= 2004 |pmid= 15296757 |doi= 10.1016/j.cub.2004.06.050 }}
- {{cite journal |vauthors=Collins JE, Wright CL, Edwards CA |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |display-authors=etal}}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal |vauthors=Haché G, Liddament MT, Harris RS |title=The retroviral hypermutation specificity of APOBEC3F and APOBEC3G is governed by the C-terminal DNA cytosine deaminase domain. |journal=J. Biol. Chem. |volume=280 |issue= 12 |pages= 10920–4 |year= 2005 |pmid= 15647250 |doi= 10.1074/jbc.M500382200 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
- {{cite journal |vauthors=Zennou V, Bieniasz PD |title=Comparative analysis of the antiretroviral activity of APOBEC3G and APOBEC3F from primates. |journal=Virology |volume=349 |issue= 1 |pages= 31–40 |year= 2006 |pmid= 16460778 |doi= 10.1016/j.virol.2005.12.035 }}
- {{cite journal |vauthors=Tian C, Yu X, Zhang W |title=Differential requirement for conserved tryptophans in human immunodeficiency virus type 1 Vif for the selective suppression of APOBEC3G and APOBEC3F. |journal=J. Virol. |volume=80 |issue= 6 |pages= 3112–5 |year= 2006 |pmid= 16501124 |doi= 10.1128/JVI.80.6.3112-3115.2006 | pmc=1395459 |display-authors=etal}}
- {{cite journal |vauthors=Stenglein MD, Harris RS |title=APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism. |journal=J. Biol. Chem. |volume=281 |issue= 25 |pages= 16837–41 |year= 2006 |pmid= 16648136 |doi= 10.1074/jbc.M602367200 }}
- {{cite journal |vauthors=Wichroski MJ, Robb GB, Rana TM |title=Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. |journal=PLoS Pathog. |volume=2 |issue= 5 |pages= e41 |year= 2006 |pmid= 16699599 |doi= 10.1371/journal.ppat.0020041 | pmc=1458959 }}
{{refend}}{{Carbon-nitrogen non-peptide hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{gene-22-stub}} 1 : EC 3.5.4 |