| 释义 |
- Function
- References
- External links
- Further reading
{{Infobox_gene}}DNA dC->dU-editing enzyme APOBEC-3H, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H or APOBEC-related protein 10, is a protein that in humans is encoded by the APOBEC3H gene.[1] Function This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC) family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistance to human immunodeficiency virus type 1 infection in certain populations. There are only one to two members of this family of genes in nonprimate mammals but at least seven members in primates. APOBEC3H is an antiviral effector. In Old world monkeys APOBEC3H has efficient antiviral activity against primate lentiviruses and it is sensitive to inactivation by the simian immunodeficiency virus Vif protein, and is capable of hypermutating retroviral genomes. The typical human APOBEC3H gene is inherently poorly expressed in primate cells and is ineffective at inhibiting retroviral replication.[2] Importantly, different people have different strengths and potencies of APOBEC3H. People with version of the gene for APOBEC3H which produce stable variations of the protein can successfully limited HIV-1's ability to replicate.[3] References1. ^{{cite web | title = Entrez Gene: apolipoprotein B mRNA editing enzyme| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=164668| accessdate = }}
2. ^{{cite journal |vauthors=OhAinle M, Kerns JA, Malik HS, Emerman M | title = Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H | journal = J. Virol. | volume = 80 | issue = 8 | pages = 3853–62 | year = 2006 | pmid = 16571802 | pmc = 1440450 | doi = 10.1128/JVI.80.8.3853-3862.2006 }}
3. ^{{cite journal |vauthors=Refsland EW, Hultquist JF, Luengas EM, Ikeda T, Shaban NM, Law EK, Brown WL, Reilly C, Emerman M, Harris RS | title = Natural Polymorphisms in Human APOBEC3H and HIV-1 Vif Combine in Primary T Lymphocytes to Affect Viral G-to-A Mutation Levels and Infectivity | journal = PLoS Genet. | volume = 10 | issue = 11 | pages = e1004761 | year = 2014 | pmid = 25411794 | pmc = 4238949 | doi = 10.1371/journal.pgen.1004761 }}
External links- {{UCSC gene info|APOBEC3H}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Wedekind JE, Dance GS, Sowden MP, Smith HC |title=Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business. |journal=Trends Genet. |volume=19 |issue= 4 |pages= 207–16 |year= 2003 |pmid= 12683974 |doi=10.1016/S0168-9525(03)00054-4 }}
- {{cite journal |vauthors=OhAinle M, Kerns JA, Malik HS, Emerman M |title=Adaptive Evolution and Antiviral Activity of the Conserved Mammalian Cytidine Deaminase APOBEC3H |journal=J. Virol. |volume=80 |issue= 8 |pages= 3853–62 |year= 2006 |pmid= 16571802 |pmc=1440450 |doi= 10.1128/JVI.80.8.3853-3862.2006 }}
- {{cite journal |vauthors=Vartanian JP, Guétard D, Henry M, Wain-Hobson S |title=Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions |journal=Science |volume=320 |issue= 5873 |pages= 230–3 |year= 2008 |pmid= 18403710 |doi= 10.1126/science.1153201 }}
- {{cite journal |vauthors=Ooms M, Majdak S, Seibert CW |title=The Localization of APOBEC3H Variants in HIV-1 Virions Determines Their Antiviral Activity |journal=J. Virol. |volume=84 |issue= 16 |pages= 7961–9 |year= 2010 |pmid= 20519396 |pmc=2916534 |doi= 10.1128/JVI.00754-10 |display-authors=etal}}
- {{cite journal |vauthors=Tan L, Sarkis PT, Wang T |title=Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1 |journal=FASEB J. |volume=23 |issue= 1 |pages= 279–87 |year= 2009 |pmid= 18827027 |pmc=2626612 |doi= 10.1096/fj.07-088781 |display-authors=etal}}
- {{cite journal |vauthors=Collins JE, Wright CL, Edwards CA |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2004 |pmid= 15461802 |pmc=545604 |doi= 10.1186/gb-2004-5-10-r84 |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |pmc=139241 |doi= 10.1073/pnas.242603899 |display-authors=etal}}
- {{cite journal |vauthors=Harari A, Ooms M, Mulder LC, Simon V |title=Polymorphisms and Splice Variants Influence the Antiretroviral Activity of Human APOBEC3H |journal=J. Virol. |volume=83 |issue= 1 |pages= 295–303 |year= 2009 |pmid= 18945781 |pmc=2612324 |doi= 10.1128/JVI.01665-08 }}
- {{cite journal |vauthors=Zhen A, Wang T, Zhao K |title=A Single Amino Acid Difference in Human APOBEC3H Variants Determines HIV-1 Vif Sensitivity |journal=J. Virol. |volume=84 |issue= 4 |pages= 1902–11 |year= 2010 |pmid= 19939923 |pmc=2812409 |doi= 10.1128/JVI.01509-09 |display-authors=etal}}
- {{cite journal |vauthors=OhAinle M, Kerns JA, Li MM |title=Anti-retroelement Activity of APOBEC3H was Lost Twice in Recent Human Evolution |journal=Cell Host Microbe |volume=4 |issue= 3 |pages= 249–59 |year= 2008 |pmid= 18779051 |pmc=2608726 |doi= 10.1016/j.chom.2008.07.005 |display-authors=etal}}
- {{cite journal |vauthors=Köck J, Blum HE |title=Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H |journal=J. Gen. Virol. |volume=89 |issue= Pt 5 |pages= 1184–91 |year= 2008 |pmid= 18420796 |doi= 10.1099/vir.0.83507-0 }}
- {{cite journal |vauthors=Li MM, Wu LI, Emerman M |title=The Range of Human APOBEC3H Sensitivity to Lentiviral Vif Proteins |journal=J. Virol. |volume=84 |issue= 1 |pages= 88–95 |year= 2010 |pmid= 19828612 |pmc=2798431 |doi= 10.1128/JVI.01344-09 }}
- {{cite journal |vauthors=Dang Y, Siew LM, Wang X |title=Human Cytidine Deaminase APOBEC3H Restricts HIV-1 Replication |journal=J. Biol. Chem. |volume=283 |issue= 17 |pages= 11606–14 |year= 2008 |pmid= 18299330 |pmc=2430661 |doi= 10.1074/jbc.M707586200 |display-authors=etal}}
{{refend}}{{Carbon-nitrogen non-peptide hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{gene-22-stub}} 1 : EC 3.5.4 |