“APOL3”的意思、由来-开放百科全书

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. In addition, expression of this gene is upregulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Six transcript variants encoding three different isoforms have been found for this gene.^[2]

References

1. ^{{cite journal |vauthors=Page NM, Butlin DJ, Lomthaisong K, Lowry PJ | title = The human apolipoprotein L gene cluster: identification, classification, and sites of distribution | journal = Genomics | volume = 74 | issue = 1 | pages = 71–8 |date=May 2001 | pmid = 11374903 | pmc = | doi = 10.1006/geno.2001.6534 }}
2. ^¹{{cite web | title = Entrez Gene: APOL3 apolipoprotein L, 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80833| accessdate = }}

Further reading

{{cite journal | author=Horrevoets AJ |title=Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes |journal=Blood |volume=93 |issue= 10 |pages= 3418–31 |year= 1999 |pmid= 10233894 |doi= |name-list-format=vanc| author2=Fontijn RD | author3=van Zonneveld AJ | display-authors=3 | last4=De Vries | first4=CJ | last5=Ten Cate | first5=JW | last6=Pannekoek | first6=H }}

{{cite journal | author=Dunham I |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 |name-list-format=vanc| author2=Shimizu N | author3=Roe BA | display-authors=3 | last4=Bruskiewich | first4=R. | last5=Beare | first5=D. M. | last6=Clamp | first6=M. | last7=Smink | first7=L. J. | last8=Ainscough | first8=R. | last9=Almeida | first9=J. P. }}

{{cite journal | author=Duchateau PN |title=Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene |journal=J. Lipid Res. |volume=42 |issue= 4 |pages= 620–30 |year= 2001 |pmid= 11290834 |doi= |name-list-format=vanc| author2=Pullinger CR | author3=Cho MH | display-authors=3 | last4=Eng | first4=C | last5=Kane | first5=JP }}

{{cite journal |vauthors=Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ |title=The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue |journal=Genomics |volume=79 |issue= 4 |pages= 539–46 |year= 2002 |pmid= 11944986 |doi= 10.1006/geno.2002.6729 }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Matsuda A |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406 |name-list-format=vanc| author2=Suzuki Y | author3=Honda G | display-authors=3 | last4=Muramatsu | first4=Shuji | last5=Matsuzaki | first5=Osamu | last6=Nagano | first6=Yukiko | last7=Doi | first7=Takahiro | last8=Shimotohno | first8=Kunitada | last9=Harada | first9=Takeshi }}

{{cite journal | author=Collins JE |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |name-list-format=vanc| author2=Wright CL | author3=Edwards CA | display-authors=3 | last4=Davis | first4=Matthew P | last5=Grinham | first5=James A | last6=Cole | first6=Charlotte G | last7=Goward | first7=Melanie E | last8=Aguado | first8=Begoña | last9=Mallya | first9=Meera }}

{{cite journal | author=Ma J |title=Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects |journal=Atherosclerosis |volume=191 |issue= 1 |pages= 63–72 |year= 2007 |pmid= 16806233 |doi= 10.1016/j.atherosclerosis.2006.05.032 |name-list-format=vanc| author2=Dempsey AA | author3=Stamatiou D | display-authors=3 | last4=Marshall | first4=K.Wayne | last5=Liew | first5=Choong-Chin }}

References

External links

Further reading