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词条 ARHGEF9
释义

  1. Function

  2. Interactions

  3. References

  4. External links

  5. Further reading

{{Infobox_gene}}Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.[1][2][3]

Function

ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.[supplied by OMIM][3]

Interactions

ARHGEF9 has been shown to interact with GPHN[4] and SMURF1.[5]

References

1. ^{{cite journal | vauthors = Reid T, Bathoorn A, Ahmadian MR, Collard JG | title = Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42 | journal = J Biol Chem | volume = 274 | issue = 47 | pages = 33587–93 | date = Dec 1999 | pmid = 10559246 | pmc = | doi = 10.1074/jbc.274.47.33587 }}
2. ^{{cite journal | vauthors = Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 4 | issue = 5 | pages = 307–13 | date = Feb 1998 | pmid = 9455477 | pmc = | doi = 10.1093/dnares/4.5.307 }}
3. ^1 {{cite web | title = Entrez Gene: ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23229| accessdate = }}
4. ^{{cite journal | vauthors = Kins S, Betz H, Kirsch J | title = Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin | journal = Nat. Neurosci. | volume = 3 | issue = 1 | pages = 22–9 | year = 2000 | pmid = 10607391 | doi = 10.1038/71096 }}
5. ^{{cite journal | vauthors = Yamaguchi K, Ohara O, Ando A, Nagase T | title = Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway | journal = Biol. Chem. | volume = 389 | issue = 4 | pages = 405–13 | date = Apr 2008 | pmid = 18208356 | doi = 10.1515/BC.2008.036 }}

External links

  • {{UCSC gene info|ARHGEF9}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions | journal = Genome Res. | volume = 14 | issue = 9 | pages = 1711–8 | year = 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
  • {{cite journal | vauthors = Harvey K, Duguid IC, Alldred MJ, Beatty SE, Ward H, Keep NH, Lingenfelter SE, Pearce BR, Lundgren J, Owen MJ, Smart TG, Lüscher B, Rees MI, Harvey RJ | title = The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering | journal = J. Neurosci. | volume = 24 | issue = 25 | pages = 5816–26 | year = 2004 | pmid = 15215304 | doi = 10.1523/JNEUROSCI.1184-04.2004 }}
  • {{cite journal | vauthors = Grosskreutz Y, Hermann A, Kins S, Fuhrmann JC, Betz H, Kneussel M | title = Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin | journal = Biol. Chem. | volume = 382 | issue = 10 | pages = 1455–62 | year = 2002 | pmid = 11727829 | doi = 10.1515/BC.2001.179 }}
  • {{cite journal | vauthors = Kins S, Betz H, Kirsch J | title = Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin | journal = Nat. Neurosci. | volume = 3 | issue = 1 | pages = 22–9 | year = 2000 | pmid = 10607391 | doi = 10.1038/71096 }}
{{refend}}{{PDB Gallery|geneid=23229}}{{gene-X-stub}}
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