Gristle may refer to:

• Cartilage, when present in meat
• Throbbing Gristle, an English avant-garde music and visual arts group
• Gristle (G.I. Joe), a fictional villain in the G.I. Joe universe
• Puppy Gristle, a 2002 album by Skinny Puppy
• The House of Gristle, a 1994 British television series

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