| 释义 |
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{{Infobox_gene}}Cysteine protease ATG4A is an enzyme that in humans is encoded by the ATG4A gene.[1][2][3]Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodelling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.[3] References1. ^{{cite journal | vauthors = Marino G, Uria JA, Puente XS, Quesada V, Bordallo J, Lopez-Otin C | title = Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy | journal = J Biol Chem | volume = 278 | issue = 6 | pages = 3671–8 |date=Feb 2003 | pmid = 12446702 | pmc = | doi = 10.1074/jbc.M208247200 }}
2. ^{{cite journal | vauthors = Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z | title = The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A | journal = J Biol Chem | volume = 278 | issue = 16 | pages = 14053–8 |date=Apr 2003 | pmid = 12473658 | pmc = | doi = 10.1074/jbc.M212108200 }}
3. ^1 {{cite web | title = Entrez Gene: ATG4A ATG4 autophagy related 4 homolog A (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115201| accessdate = }}
External linksFurther reading{{refbegin | 2}}- {{cite journal | vauthors=Scherz-Shouval R, Shvets E, Fass E |title=Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 |journal=EMBO J. |volume=26 |issue= 7 |pages= 1749–60 |year= 2007 |pmid= 17347651 |doi= 10.1038/sj.emboj.7601623 | pmc=1847657 |display-authors=etal}}
- {{cite journal | vauthors=Ross MT, Grafham DV, Coffey AJ |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Kabeya Y, Mizushima N, Yamamoto A |title=LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation |journal=J. Cell Sci. |volume=117 |issue= Pt 13 |pages= 2805–12 |year= 2005 |pmid= 15169837 |doi= 10.1242/jcs.01131 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
{{refend}}{{PDB Gallery|geneid=115201}}{{gene-X-stub}} |