| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}Plasma membrane calcium-transporting ATPase 1 is an enzyme that in humans is encoded by the ATP2B1 gene.[1][2]The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified.[3] References1. ^{{cite journal | vauthors = Olson S, Wang MG, Carafoli E, Strehler EE, McBride OW | title = Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23 | journal = Genomics | volume = 9 | issue = 4 | pages = 629–41 |date=Jul 1991 | pmid = 1674727 | pmc = | doi =10.1016/0888-7543(91)90356-J }}
2. ^{{cite web | title = Entrez Gene: ATP2B1 ATPase, Ca++ transporting, plasma membrane 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=490| accessdate = }}
3. ^{{cite web | title = Entrez Gene: ATP2B1 ATPase, Ca++ transporting, plasma membrane 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=490| accessdate = }}
External links- {{UCSC gene info|ATP2B1}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Møller JV, Juul B, le Maire M |title=Structural organization, ion transport, and energy transduction of P-type ATPases. |journal=Biochim. Biophys. Acta |volume=1286 |issue= 1 |pages= 1–51 |year= 1996 |pmid= 8634322 |doi= 10.1016/0304-4157(95)00017-8}}
- {{cite journal | vauthors=Strehler EE, Zacharias DA |title=Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. |journal=Physiol. Rev. |volume=81 |issue= 1 |pages= 21–50 |year= 2001 |pmid= 11152753 |doi= }}
- {{cite journal | vauthors=Strehler EE, Treiman M |title=Calcium pumps of plasma membrane and cell interior. |journal=Curr. Mol. Med. |volume=4 |issue= 3 |pages= 323–35 |year= 2004 |pmid= 15101689 |doi=10.2174/1566524043360735 }}
- {{cite journal | vauthors=Kessler F, Falchetto R, Heim R |title=Study of calmodulin binding to the alternatively spliced C-terminal domain of the plasma membrane Ca2+ pump. |journal=Biochemistry |volume=31 |issue= 47 |pages= 11785–92 |year= 1992 |pmid= 1332771 |doi=10.1021/bi00162a016 |display-authors=etal}}
- {{cite journal | vauthors=Wang KK, Wright LC, Machan CL |title=Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes. |journal=J. Biol. Chem. |volume=266 |issue= 14 |pages= 9078–85 |year= 1991 |pmid= 1827443 |doi= |display-authors=etal}}
- {{cite journal | vauthors=Strehler EE, Strehler-Page MA, Vogel G, Carafoli E |title=mRNAs for plasma membrane calcium pump isoforms differing in their regulatory domain are generated by alternative splicing that involves two internal donor sites in a single exon. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 18 |pages= 6908–12 |year= 1989 |pmid= 2528729 |doi=10.1073/pnas.86.18.6908 | pmc=297959 }}
- {{cite journal | vauthors=James PH, Pruschy M, Vorherr TE |title=Primary structure of the cAMP-dependent phosphorylation site of the plasma membrane calcium pump. |journal=Biochemistry |volume=28 |issue= 10 |pages= 4253–8 |year= 1989 |pmid= 2548572 |doi=10.1021/bi00436a020 |display-authors=etal}}
- {{cite journal | vauthors=Verma AK, Filoteo AG, Stanford DR |title=Complete primary structure of a human plasma membrane Ca2+ pump. |journal=J. Biol. Chem. |volume=263 |issue= 28 |pages= 14152–9 |year= 1988 |pmid= 2844759 |doi= |display-authors=etal}}
- {{cite journal | vauthors=Howard A, Legon S, Walters JR |title=Human and rat intestinal plasma membrane calcium pump isoforms. |journal=Am. J. Physiol. |volume=265 |issue= 5 Pt 1 |pages= G917–25 |year= 1993 |pmid= 7694502 |doi= }}
- {{cite journal | vauthors=Stauffer TP, Hilfiker H, Carafoli E, Strehler EE |title=Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. |journal=J. Biol. Chem. |volume=269 |issue= 50 |pages= 32022 |year= 1995 |pmid= 7989379 |doi= }}
- {{cite journal | vauthors=Stauffer TP, Hilfiker H, Carafoli E, Strehler EE |title=Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. |journal=J. Biol. Chem. |volume=268 |issue= 34 |pages= 25993–6003 |year= 1994 |pmid= 8245032 |doi= }}
- {{cite journal | vauthors=Kumar R, Haugen JD, Penniston JT |title=Molecular cloning of a plasma membrane calcium pump from human osteoblasts. |journal=J. Bone Miner. Res. |volume=8 |issue= 4 |pages= 505–13 |year= 1993 |pmid= 8386431 |doi=10.1002/jbmr.5650080415 }}
- {{cite journal | vauthors=Hilfiker H, Strehler-Page MA, Stauffer TP |title=Structure of the gene encoding the human plasma membrane calcium pump isoform 1. |journal=J. Biol. Chem. |volume=268 |issue= 26 |pages= 19717–25 |year= 1993 |pmid= 8396145 |doi= |display-authors=etal}}
- {{cite journal | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
- {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
- {{cite journal | vauthors=Benkwitz C, Kubisch C, Kraft K, Neyses L |title=Investigation of the Met-267 Arg exchange in isoform 1 of the human plasma membrane calcium pump in patients with essential hypertension by the amplification-created restriction site technique. |journal=J. Mol. Med. |volume=75 |issue= 1 |pages= 62–6 |year= 1997 |pmid= 9020386 |doi=10.1007/s001090050088 }}
- {{cite journal | vauthors=Yu W, Andersson B, Worley KC |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |display-authors=etal}}
- {{cite journal | vauthors=Elshorst B, Hennig M, Försterling H |title=NMR solution structure of a complex of calmodulin with a binding peptide of the Ca2+ pump. |journal=Biochemistry |volume=38 |issue= 38 |pages= 12320–32 |year= 1999 |pmid= 10493800 |doi=10.1021/bi9908235 |display-authors=etal}}
{{refend}}{{ATPases}}{{gene-12-stub}} |