| 释义 |
- Function
- References
- External links
- Further reading
{{Infobox_gene}}ATP synthase F1 subunit beta, mitochondrial is an enzyme that in humans is encoded by the ATP5F1B gene.[1][2] Function This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core.[2] References 1. ^{{cite journal | vauthors = Neckelmann N, Warner CK, Chung A, Kudoh J, Minoshima S, Fukuyama R, Maekawa M, Shimizu Y, Shimizu N, Liu JD | title = The human ATP synthase beta subunit gene: sequence analysis, chromosome assignment, and differential expression | journal = Genomics | volume = 5 | issue = 4 | pages = 829–43 | date = Jan 1990 | pmid = 2687158 | pmc = | doi = 10.1016/0888-7543(89)90125-0 }}
2. ^1 {{cite web | title = Entrez Gene: ATP5F1B ATP synthase F1 subunit beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=506| accessdate = }}
External links- {{UCSC gene info|ATP5F1B}}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Maguire D, Shah J, McCabe M | title = Assaying ATP synthase rotor activity | journal = Adv. Exp. Med. Biol. | volume = 578 | issue = | pages = 67–72 | year = 2007 | pmid = 16927672 | doi = 10.1007/0-387-29540-2_11 | isbn = 978-0-387-29543-5 | series = Advances in Experimental Medicine and Biology }}
- {{cite journal | vauthors = Dawson SJ, White LA | title = Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin | journal = J. Infect. | volume = 24 | issue = 3 | pages = 317–20 | year = 1992 | pmid = 1602151 | doi = 10.1016/S0163-4453(05)80037-4 }}
- {{cite journal | vauthors = Ohta S, Kagawa Y | title = Human F1-ATPase: molecular cloning of cDNA for the beta subunit | journal = J. Biochem. | volume = 99 | issue = 1 | pages = 135–41 | year = 1986 | pmid = 2870059 | doi = }}
- {{cite journal | vauthors = Wallace DC, Ye JH, Neckelmann SN, Singh G, Webster KA, Greenberg BD | title = Sequence analysis of cDNAs for the human and bovine ATP synthase beta subunit: mitochondrial DNA genes sustain seventeen times more mutations | journal = Curr. Genet. | volume = 12 | issue = 2 | pages = 81–90 | year = 1988 | pmid = 2896550 | doi = 10.1007/BF00434661 }}
- {{cite journal | vauthors = Ohta S, Tomura H, Matsuda K, Kagawa Y | title = Gene structure of the human mitochondrial adenosine triphosphate synthase beta subunit | journal = J. Biol. Chem. | volume = 263 | issue = 23 | pages = 11257–62 | year = 1988 | pmid = 2900241 | doi = }}
- {{cite journal | vauthors = Villena JA, Martin I, Viñas O, Cormand B, Iglesias R, Mampel T, Giralt M, Villarroya F | title = ETS transcription factors regulate the expression of the gene for the human mitochondrial ATP synthase beta-subunit | journal = J. Biol. Chem. | volume = 269 | issue = 51 | pages = 32649–54 | year = 1995 | pmid = 7798271 | doi = }}
- {{cite journal | vauthors = Abrahams JP, Leslie AG, Lutter R, Walker JE | title = Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria | journal = Nature | volume = 370 | issue = 6491 | pages = 621–8 | year = 1994 | pmid = 8065448 | doi = 10.1038/370621a0 }}
- {{cite journal | vauthors = Elston T, Wang H, Oster G | title = Energy transduction in ATP synthase | journal = Nature | volume = 391 | issue = 6666 | pages = 510–3 | year = 1998 | pmid = 9461222 | doi = 10.1038/35185 }}
- {{cite journal | vauthors = Wang H, Oster G | title = Energy transduction in the F1 motor of ATP synthase | journal = Nature | volume = 396 | issue = 6708 | pages = 279–82 | year = 1998 | pmid = 9834036 | doi = 10.1038/24409 }}
- {{cite journal | vauthors = Moser TL, Stack MS, Asplin I, Enghild JJ, Højrup P, Everitt L, Hubchak S, Schnaper HW, Pizzo SV | title = Angiostatin binds ATP synthase on the surface of human endothelial cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 6 | pages = 2811–6 | year = 1999 | pmid = 10077593 | pmc = 15851 | doi = 10.1073/pnas.96.6.2811 }}
- {{cite journal | vauthors = Wang ZG, White PS, Ackerman SH | title = Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria | journal = J. Biol. Chem. | volume = 276 | issue = 33 | pages = 30773–8 | year = 2001 | pmid = 11410595 | doi = 10.1074/jbc.M104133200 }}
- {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
- {{cite journal | vauthors = Ackerman SH | title = Atp11p and Atp12p are chaperones for F(1)-ATPase biogenesis in mitochondria | journal = Biochim. Biophys. Acta | volume = 1555 | issue = 1–3 | pages = 101–5 | year = 2002 | pmid = 12206899 | doi = 10.1016/S0005-2728(02)00262-1 }}
- {{cite journal | vauthors = Martinez LO, Jacquet S, Esteve JP, Rolland C, Cabezón E, Champagne E, Pineau T, Georgeaud V, Walker JE, Tercé F, Collet X, Perret B, Barbaras R | title = Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis | journal = Nature | volume = 421 | issue = 6918 | pages = 75–9 | year = 2003 | pmid = 12511957 | doi = 10.1038/nature01250 }}
- {{cite journal | vauthors = Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA | title = Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport | journal = Exp. Cell Res. | volume = 289 | issue = 2 | pages = 211–21 | year = 2003 | pmid = 14499622 | doi = 10.1016/S0014-4827(03)00261-1 }}
- {{cite journal | vauthors = Cross RL | title = Molecular motors: turning the ATP motor | journal = Nature | volume = 427 | issue = 6973 | pages = 407–8 | year = 2004 | pmid = 14749816 | doi = 10.1038/427407b }}
- {{cite journal | vauthors = Aboulaich N, Vainonen JP, Strålfors P, Vener AV | title = Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes | journal = Biochem. J. | volume = 383 | issue = Pt 2 | pages = 237–48 | year = 2005 | pmid = 15242332 | pmc = 1134064 | doi = 10.1042/BJ20040647 }}
- {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Curr. Biol. | volume = 14 | issue = 16 | pages = 1436–50 | year = 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
{{refend}}{{PDB Gallery|geneid=506}}{{gene-12-stub}} |