“ATP5F1”的意思、由来-开放百科全书

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel.^[2]

The b subunits are part of the peripheral stalk that links the F1 and FO complexes together, and which acts as a stator to prevent certain subunits from rotating with the central rotary element. The peripheral stalk differs in subunit composition between mitochondrial, chloroplast and bacterial F-ATPases. In bacterial and chloroplast F-ATPases, the peripheral stalk is composed of one copy of the delta subunit (homologous to OSCP in mitochondria), and two copies of subunit b in bacteria, or one copy each of subunits b and b' in chloroplasts and photosynthetic bacteria.^[3]

References

1. ^{{cite journal | vauthors = Higuti T, Tsurumi C, Osaka F, Kawamura Y, Tsujita H, Yoshihara Y, Tani I, Tanaka K, Ichihara A | title = Molecular cloning of cDNA for the import precursor of human subunit B of H(+)-ATP synthase in mitochondria | journal = Biochem Biophys Res Commun | volume = 178 | issue = 3 | pages = 1014–20 |date=Sep 1991 | pmid = 1831354 | pmc = | doi =10.1016/0006-291X(91)90993-H }}
2. ^¹{{cite web | title = Entrez Gene: ATP5PB ATP synthase peripheral stalk-membrane subunit b| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=515| accessdate = }}
3. ^{{cite journal | vauthors = Carbajo RJ, Kellas FA, Runswick MJ, Montgomery MG, Walker JE, Neuhaus D | title = Structure of the F1-binding domain of the stator of bovine F1Fo-ATPase and how it binds an alpha-subunit | journal = J. Mol. Biol. | volume = 351 | issue = 4 | pages = 824–38 |date=August 2005 | pmid = 16045926 | doi = 10.1016/j.jmb.2005.06.012 | url = }}

Further reading

{{cite journal | vauthors=Gay NJ, Walker JE |title=Two genes encoding the bovine mitochondrial ATP synthase proteolipid specify precursors with different import sequences and are expressed in a tissue-specific manner |journal=EMBO J. |volume=4 |issue= 13A |pages= 3519–24 |year= 1986 |pmid= 2868890 |doi= | pmc=554691 }}

{{cite journal | vauthors=Farrell LB, Nagley P |title=Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex |journal=Biochem. Biophys. Res. Commun. |volume=144 |issue= 3 |pages= 1257–64 |year= 1987 |pmid= 2883974 |doi=10.1016/0006-291X(87)91446-X }}

{{cite journal | author=Houstĕk J |title=The expression of subunit c correlates with and thus may limit the biosynthesis of the mitochondrial F0F1-ATPase in brown adipose tissue |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7689–94 |year= 1995 |pmid= 7706317 |doi=10.1074/jbc.270.13.7689 |name-list-format=vanc| author2=Andersson U | author3=Tvrdík P | display-authors=3 | last4=Nedergaard | first4=J | last5=Cannon | first5=B }}

{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}

{{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=Akira | last5=Sugano | first5=Sumio }}

{{cite journal | vauthors=Elston T, Wang H, Oster G |title=Energy transduction in ATP synthase |journal=Nature |volume=391 |issue= 6666 |pages= 510–3 |year= 1998 |pmid= 9461222 |doi= 10.1038/35185 }}

{{cite journal | vauthors=Wang H, Oster G |title=Energy transduction in the F1 motor of ATP synthase |journal=Nature |volume=396 |issue= 6708 |pages= 279–82 |year= 1998 |pmid= 9834036 |doi= 10.1038/24409 }}

{{cite journal | author=Jia L |title=Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis |journal=Genomics |volume=79 |issue= 1 |pages= 7–17 |year= 2002 |pmid= 11827452 |doi= 10.1006/geno.2001.6683 |name-list-format=vanc| author2=Young MF | author3=Powell J | display-authors=3 | last4=Yang | first4=Liming | last5=Ho | first5=Nicola C. | last6=Hotchkiss | first6=Robert | last7=Robey | first7=Pamela Gehron | last8=Francomano | first8=Clair A. }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Cross RL |title=Molecular motors: turning the ATP motor |journal=Nature |volume=427 |issue= 6973 |pages= 407–8 |year= 2004 |pmid= 14749816 |doi= 10.1038/427407b }}

{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{cite journal | author=Gregory SG |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |name-list-format=vanc| author2=Barlow KF | author3=McLay KE | display-authors=3 | last4=Kaul | first4=R. | last5=Swarbreck | first5=D. | last6=Dunham | first6=A. | last7=Scott | first7=C. E. | last8=Howe | first8=K. L. | last9=Woodfine | first9=K. }}

{{cite journal | author=Ewing RM |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |name-list-format=vanc| author2=Chu P | author3=Elisma F | display-authors=3 | last4=Li | first4=Hongyan | last5=Taylor | first5=Paul | last6=Climie | first6=Shane | last7=McBroom-Cerajewski | first7=Linda | last8=Robinson | first8=Mark D | last9=O'Connor | first9=Liam }}

2 : Enzymes|Genes

References

External links

Further reading