| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}The human gene ATP6AP1 encodes the S1 subunit of the enzyme V-type proton ATPase.[1][2][3] This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is composed of a cytosolic, V1, (site of the ATP catalytic site) and a transmembrane, V0, domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules.[3] References1. ^{{cite journal | vauthors = Chen EY, Zollo M, Mazzarella R, Ciccodicola A, Chen CN, Zuo L, Heiner C, Burough F, Repetto M, Schlessinger D, D'Urso M | title = Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci | journal = Hum Mol Genet | volume = 5 | issue = 5 | pages = 659–68 |date=Jun 1997 | pmid = 8733135 | pmc = | doi =10.1093/hmg/5.5.659 }}
2. ^{{cite journal | vauthors = Sedlacek Z, Korn B, Konecki DS, Siebenhaar R, Coy JF, Kioschis P, Poustka A | title = Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection | journal = Hum Mol Genet | volume = 2 | issue = 11 | pages = 1865–9 |date=Feb 1994 | pmid = 8281148 | pmc = | doi =10.1093/hmg/2.11.1865 }}
3. ^1 {{cite web | title = Entrez Gene: ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=537| accessdate = }}
External links- {{UCSC gene info|ATP6AP1}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Finbow ME, Harrison MA |title=The vacuolar H+-ATPase: a universal proton pump of eukaryotes |journal=Biochem. J. |volume=324 |issue= 3|pages= 697–712 |year= 1997 |pmid= 9210392 |doi= 10.1042/bj3240697| pmc=1218484 }}
- {{cite journal | vauthors=Stevens TH, Forgac M |title=Structure, function and regulation of the vacuolar (H+)-ATPase |journal=Annu. Rev. Cell Dev. Biol. |volume=13 |issue= |pages= 779–808 |year= 1998 |pmid= 9442887 |doi= 10.1146/annurev.cellbio.13.1.779 }}
- {{cite journal | vauthors=Nelson N, Harvey WR |title=Vacuolar and plasma membrane proton-adenosinetriphosphatases |journal=Physiol. Rev. |volume=79 |issue= 2 |pages= 361–85 |year= 1999 |pmid= 10221984 |doi= 10.1152/physrev.1999.79.2.361}}
- {{cite journal | author=Forgac M |title=Structure and properties of the vacuolar (H+)-ATPases |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 12951–4 |year= 1999 |pmid= 10224039 |doi=10.1074/jbc.274.19.12951 }}
- {{cite journal | author=Kane PM |title=Introduction: V-ATPases 1992-1998 |journal=J. Bioenerg. Biomembr. |volume=31 |issue= 1 |pages= 3–5 |year= 1999 |pmid= 10340843 |doi=10.1023/A:1001884227654 }}
- {{cite journal | vauthors=Wieczorek H, Brown D, Grinstein S |title=Animal plasma membrane energization by proton-motive V-ATPases |journal=BioEssays |volume=21 |issue= 8 |pages= 637–48 |year= 1999 |pmid= 10440860 |doi= 10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W |display-authors=etal}}
- {{cite journal | vauthors=Yokoi H, Hadano S, Kogi M |title=Isolation of expressed sequences encoded by the human Xq terminal portion using microclone probes generated by laser microdissection |journal=Genomics |volume=20 |issue= 3 |pages= 404–11 |year= 1994 |pmid= 8034313 |doi= 10.1006/geno.1994.1194 |display-authors=etal}}
- {{cite journal | vauthors=Holthuis JC, Jansen EJ, Schoonderwoert VT |title=Biosynthesis of the vacuolar H+-ATPase accessory subunit Ac45 in Xenopus pituitary |journal=Eur. J. Biochem. |volume=262 |issue= 2 |pages= 484–91 |year= 1999 |pmid= 10336633 |doi=10.1046/j.1432-1327.1999.00396.x |display-authors=etal}}
- {{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
- {{cite journal | vauthors=Bagai S, Rubio E, Cheng JF |title=Fibroblast growth factor-10 is a mitogen for urothelial cells |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23828–37 |year= 2002 |pmid= 11923311 |doi= 10.1074/jbc.M201658200 |display-authors=etal}}
- {{cite journal | vauthors=Hodi FS, Schmollinger JC, Soiffer RJ |title=ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 10 |pages= 6919–24 |year= 2002 |pmid= 11983866 |doi= 10.1073/pnas.102025999 | pmc=124504 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
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