| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.[1][2][3]This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.[3] In melanocytic cells ATP6V1B2 gene expression may be regulated by MITF.[4] References1. ^{{cite journal | vauthors = Bernasconi P, Rausch T, Struve I, Morgan L, Taiz L | title = An mRNA from human brain encodes an isoform of the B subunit of the vacuolar H(+)-ATPase | journal = J Biol Chem | volume = 265 | issue = 29 | pages = 17428–31 |date=Nov 1990 | pmid = 2145275 | pmc = | doi = }}
2. ^{{cite journal | vauthors = Smith AN, Lovering RC, Futai M, Takeda J, Brown D, Karet FE | title = Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes | journal = Mol Cell | volume = 12 | issue = 4 | pages = 801–3 |date=Oct 2003 | pmid = 14580332 | pmc = | doi =10.1016/S1097-2765(03)00397-6 }}
3. ^1 {{cite web | title = Entrez Gene: ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=526| accessdate = }}
4. ^{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x |display-authors=etal}}
External links- {{UCSC gene info|ATP6V1B2}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Finbow ME, Harrison MA |title=The vacuolar H+-ATPase: a universal proton pump of eukaryotes. |journal=Biochem. J. |volume=324 |issue= 3|pages= 697–712 |year= 1997 |pmid= 9210392 |doi= 10.1042/bj3240697| pmc=1218484 }}
- {{cite journal | vauthors=Stevens TH, Forgac M |title=Structure, function and regulation of the vacuolar (H+)-ATPase. |journal=Annu. Rev. Cell Dev. Biol. |volume=13 |issue= |pages= 779–808 |year= 1998 |pmid= 9442887 |doi= 10.1146/annurev.cellbio.13.1.779 }}
- {{cite journal | vauthors=Nelson N, Harvey WR |title=Vacuolar and plasma membrane proton-adenosinetriphosphatases. |journal=Physiol. Rev. |volume=79 |issue= 2 |pages= 361–85 |year= 1999 |pmid= 10221984 |doi= }}
- {{cite journal | author=Forgac M |title=Structure and properties of the vacuolar (H+)-ATPases. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 12951–4 |year= 1999 |pmid= 10224039 |doi=10.1074/jbc.274.19.12951 }}
- {{cite journal | author=Kane PM |title=Introduction: V-ATPases 1992-1998. |journal=J. Bioenerg. Biomembr. |volume=31 |issue= 1 |pages= 3–5 |year= 1999 |pmid= 10340843 |doi=10.1023/A:1001884227654 }}
- {{cite journal | vauthors=Wieczorek H, Brown D, Grinstein S |title=Animal plasma membrane energization by proton-motive V-ATPases. |journal=BioEssays |volume=21 |issue= 8 |pages= 637–48 |year= 1999 |pmid= 10440860 |doi= 10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W |display-authors=etal}}
- {{cite journal | vauthors=Nishi T, Forgac M |title=The vacuolar (H+)-ATPases--nature's most versatile proton pumps. |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 2 |pages= 94–103 |year= 2002 |pmid= 11836511 |doi= 10.1038/nrm729 }}
- {{cite journal | vauthors=Kawasaki-Nishi S, Nishi T, Forgac M |title=Proton translocation driven by ATP hydrolysis in V-ATPases. |journal=FEBS Lett. |volume=545 |issue= 1 |pages= 76–85 |year= 2003 |pmid= 12788495 |doi=10.1016/S0014-5793(03)00396-X }}
- {{cite journal | author=Morel N |title=Neurotransmitter release: the dark side of the vacuolar-H+ATPase. |journal=Biol. Cell |volume=95 |issue= 7 |pages= 453–7 |year= 2004 |pmid= 14597263 |doi=10.1016/S0248-4900(03)00075-3 }}
- {{cite journal | vauthors=Nelson RD, Guo XL, Masood K |title=Selectively amplified expression of an isoform of the vacuolar H(+)-ATPase 56-kilodalton subunit in renal intercalated cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 8 |pages= 3541–5 |year= 1992 |pmid= 1373501 |doi=10.1073/pnas.89.8.3541 | pmc=48904 |display-authors=etal}}
- {{cite journal | vauthors=Lee BS, Underhill DM, Crane MK, Gluck SL |title=Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells. |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7320–9 |year= 1995 |pmid= 7706273 |doi=10.1074/jbc.270.13.7320 }}
- {{cite journal | vauthors=van Hille B, Richener H, Schmid P |title=Heterogeneity of vacuolar H(+)-ATPase: differential expression of two human subunit B isoforms. |journal=Biochem. J. |volume=303 |issue= 1|pages= 191–8 |year= 1994 |pmid= 7945239 |doi= 10.1042/bj3030191| pmc=1137575 |display-authors=etal}}
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