| 释义 |
- Interactions
- References
- External links
- Further reading
{{Infobox_gene}}Ataxin-2-like protein is a protein that in humans is encoded by the ATXN2L gene.[1][2][3]This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.[4] InteractionsATXN2L has been shown to interact with Myeloproliferative leukemia virus oncogene.[1] References1. ^1 {{cite journal | vauthors = Meunier C, Bordereaux D, Porteu F, Gisselbrecht S, Chretien S, Courtois G | title = Cloning and characterization of a family of proteins associated with Mpl | journal = J Biol Chem | volume = 277 | issue = 11 | pages = 9139–47 |date=Mar 2002 | pmid = 11784712 | pmc = | doi = 10.1074/jbc.M105970200 }}
2. ^{{cite journal | vauthors = Figueroa KP, Pulst SM | title = Identification and expression of the gene for human ataxin-2-related protein on chromosome 16 | journal = Exp Neurol | volume = 184 | issue = 2 | pages = 669–78 |date=Feb 2004 | pmid = 14769358 | pmc = | doi = 10.1016/S0014-4886(03)00287-5 }}
3. ^{{cite web | title = Entrez Gene: ATXN2L ataxin 2-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11273| accessdate = }}
4. ^{{cite web | title = Entrez Gene: ATXN2L ataxin 2-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11273| accessdate = }}
External links- {{UCSC gene info|ATXN2L}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
- {{cite journal | vauthors=Pulst SM, Nechiporuk A, Nechiporuk T |title=Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2. |journal=Nat. Genet. |volume=14 |issue= 3 |pages= 269–76 |year= 1996 |pmid= 8896555 |doi= 10.1038/ng1196-269 |display-authors=etal}}
- {{cite journal | vauthors=Yu W, Andersson B, Worley KC |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Brill LM, Salomon AR, Ficarro SB |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d |display-authors=etal}}
- {{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Ong SE, Mittler G, Mann M |title=Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. |journal=Nat. Methods |volume=1 |issue= 2 |pages= 119–26 |year= 2005 |pmid= 15782174 |doi= 10.1038/nmeth715 }}
- {{cite journal | vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}}
- {{cite journal | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
- {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
- {{cite journal | vauthors=Nonhoff U, Ralser M, Welzel F |title=Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules. |journal=Mol. Biol. Cell |volume=18 |issue= 4 |pages= 1385–96 |year= 2007 |pmid= 17392519 |doi= 10.1091/mbc.E06-12-1120 | pmc=1838996 |display-authors=etal}}
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