| 词条 | Azalanstat |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = | IUPAC_name = 4-({[(2S,4S)-2-[2-(4-Chlorophenyl)ethyl]-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}sulfanyl)aniline | image = Azalanstat.svg | width = 275 | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | metabolism = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 143484-82-6 | ATC_prefix = None | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 70611 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C22H24ClN3O2S/c23-18-3-1-17(2-4-18)9-10-22(15-26-12-11-25-16-26)27-13-20(28-22)14-29-21-7-5-19(24)6-8-21/h1-8,11-12,16,20H,9-10,13-15,24H2/t20-,22-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = VYNIUBZKEWJOJP-UNMCSNQZSA-N | PubChem = 60876 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 54858 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 2NL79NI1WS | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D03025 | synonyms = | C=22 | H=24 | Cl=1 | N=3 | O=2 | S=1 | molecular_weight = 429.963 g/mol | smiles = Clc1ccc(cc1)CC[C@@]2(OC[C@H](O2)CSc3ccc(N)cc3)Cn4ccnc4 }}Azalanstat (INN,[1] codenamed RS-21607) is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor.[2][3] References1. ^{{cite web | title = International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names (Rec. INN): List 36 | url = http://www.who.int/medicines/publications/druginformation/innlists/RL36.pdf | publisher = World Health Organization | accessdate = 3 January 2017 | page = 141}} {{Antiobesity preparations}}{{Lipid modifying agents}}{{gastrointestinal-drug-stub}}2. ^{{cite journal | last1 = Walker | first1 = KA | last2 = Kertesz | first2 = DJ | last3 = Rotstein | first3 = DM | last4 = Swinney | first4 = DC | last5 = Berry | first5 = PW | last6 = So | first6 = OY | last7 = Webb | first7 = AS | last8 = Watson | first8 = DM | last9 = Mak | first9 = AY | last10 = Burton | first10 = PM | title = Selective Inhibition of Mammalian Lanosterol 14α-Demethylase: A Possible Strategy for Cholesterol Lowering | journal = Journal of Medicinal Chemistry | date = 23 July 1993 | volume = 36 | issue = 15 | pages = 2235–7 | doi = 10.1021/jm00067a022 | pmid = 8340925}} 3. ^{{cite journal | last1 = Burton | first1 = PM | last2 = Swinney | first2 = DC | last3 = Heller | first3 = R | last4 = Dunlap | first4 = B | last5 = Chiou | first5 = M | last6 = Malonzo | first6 = E | last7 = Haller | first7 = J | last8 = Walker | first8 = KA | last9 = Salari | first9 = A | last10 = Murakami | first10 = S | title = Azalanstat (RS-21607), a Lanosterol 14α-Demethylase Inhibitor with Cholesterol-Lowering Activity | journal = Biochemical Pharmacology | date = 8 August 1995 | volume = 50 | issue = 4 | pages = 529–44 | pmid = 7646560 | doi=10.1016/0006-2952(95)00152-p}} 7 : Antiobesity drugs|Chloroarenes|Dioxolanes|Hypolipidemic agents|Imidazoles|Lanosterol 14α-demethylase inhibitors|Thioethers |
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