| 释义 |
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{{Infobox_gene}}Zinc-alpha-2-glycoprotein is a protein that in humans is encoded by the AZGP1 gene.[1][2]This gene expresses a soluble protein that stimulates lipolysis, induces a reduction in body fat in mice, is associated with the cachexia related to cancer, and is known to be expressed in secretory cells of lung epithelium.[3] In 2009, it was found that smoking increases expression of this gene, which is why smoking cessation leads to weight gain.[3] Zinc-alpha-2-glycoprotein levels also rise with onset of Diabetes 2, which accounts for weight loss thereafter. References1. ^{{cite journal | vauthors = Ueyama H, Niwa M, Tada T, Sasaki M, Ohkubo I | title = Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene | journal = Biochem Biophys Res Commun | volume = 177 | issue = 2 | pages = 696–703 |date=Jul 1991 | pmid = 2049092 | pmc = | doi =10.1016/0006-291X(91)91844-3 }}
2. ^{{cite web | title = Entrez Gene: AZGP1 alpha-2-glycoprotein 1, zinc-binding| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=563| accessdate = }}
3. ^1 {{cite journal | title = Cigarette Smoking Induces Overexpression of a Fat-Depleting Gene AZGP1 in the Human| journal=Chest | volume=135 | issue=5 | pages=1197–208 | year=2009 | pmid=19188554 | doi = 10.1378/chest.08-1024 | last1 = Vanni | first1 = H | last2 = Kazeros | first2 = A | last3 = Wang | first3 = R | last4 = Harvey | first4 = BG | last5 = Ferris | first5 = B | last6 = De | first6 = BP | last7 = Carolan | first7 = BJ | last8 = Hübner | first8 = RH | last9 = O'Connor | first9 = TP | last10=Crystal | first10=R. G. | pmc = 2679098 | display-authors=8 }}
External linksFurther reading{{refbegin | 2}}- {{cite journal | vauthors=Freije JP, Fueyo A, Uría J, López-Otín C |title=Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues. |journal=FEBS Lett. |volume=290 |issue= 1–2 |pages= 247–9 |year= 1991 |pmid= 1915885 |doi=10.1016/0014-5793(91)81271-9 }}
- {{cite journal | vauthors=Tada T, Ohkubo I, Niwa M |title=Immunohistochemical localization of Zn-alpha 2-glycoprotein in normal human tissues |journal=J. Histochem. Cytochem. |volume=39 |issue= 9 |pages= 1221–6 |year= 1991 |pmid= 1918940 |doi= 10.1177/39.9.1918940|display-authors=etal}}
- {{cite journal | vauthors=Araki T, Gejyo F, Takagaki K |title=Complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein and its homology to histocompatibility antigens |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 3 |pages= 679–83 |year= 1988 |pmid= 3422450 |doi=10.1073/pnas.85.3.679 | pmc=279618 |display-authors=etal}}
- {{cite journal | vauthors=Shibata S, Miura K |title=Nephritogenic glycoprotein. IX. Plasma Zn-alpha2-glycoprotein as a second source of nephritogenic glycoprotein in urine |journal=Nephron |volume=31 |issue= 2 |pages= 170–6 |year= 1982 |pmid= 6896906 |doi= 10.1159/000182638}}
- {{cite journal | vauthors=Ueyama H, Deng HX, Ohkubo I |title=Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein |journal=Biochemistry |volume=32 |issue= 48 |pages= 12968–76 |year= 1994 |pmid= 8241150 |doi=10.1021/bi00211a004 }}
- {{cite journal | vauthors=Freije JP, Fueyo A, Uría JA |title=Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes |journal=Genomics |volume=18 |issue= 3 |pages= 575–87 |year= 1994 |pmid= 8307568 |doi=10.1016/S0888-7543(05)80359-3 |display-authors=etal}}
- {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
- {{cite journal | vauthors=Sánchez LM, López-Otín C, Bjorkman PJ |title=Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 9 |pages= 4626–30 |year= 1997 |pmid= 9114041 |doi=10.1073/pnas.94.9.4626 | pmc=20774 }}
- {{cite journal | vauthors=Brysk MM, Lei G, Rajaraman S |title=Gene expression of zinc-alpha 2-glycoprotein in normal human epidermal and buccal epithelia |journal=In Vivo |volume=11 |issue= 3 |pages= 271–4 |year= 1997 |pmid= 9239523 |doi= |display-authors=etal}}
- {{cite journal | vauthors=Lei G, Arany I, Selvanayagam P |title=Detection and cloning of epidermal zinc-alpha 2-glycoprotein cDNA and expression in normal human skin and in tumors |journal=J. Cell. Biochem. |volume=67 |issue= 2 |pages= 216–22 |year= 1997 |pmid= 9328826 |doi=10.1002/(SICI)1097-4644(19971101)67:2<216::AID-JCB6>3.0.CO;2-# |display-authors=etal}}
- {{cite journal | vauthors=Ogikubo O, Maeda T, Yamane T |title=Regulation of Zn-alpha2-glycoprotein-mediated cell adhesion by kininogens and their derivatives |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 1 |pages= 257–62 |year= 1998 |pmid= 9813179 |doi=10.1006/bbrc.1998.9614 |display-authors=etal}}
- {{cite journal | vauthors=Sánchez LM, Chirino AJ, Bjorkman P |title=Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules |journal=Science |volume=283 |issue= 5409 |pages= 1914–9 |year= 1999 |pmid= 10206894 |doi=10.1126/science.283.5409.1914 }}
- {{cite journal | vauthors=Lei G, Brysk H, Arany I |title=Characterization of zinc-alpha(2)-glycoprotein as a cell adhesion molecule that inhibits the proliferation of an oral tumor cell line |journal=J. Cell. Biochem. |volume=75 |issue= 1 |pages= 160–9 |year= 1999 |pmid= 10462714 |doi=10.1002/(SICI)1097-4644(19991001)75:1<160::AID-JCB16>3.0.CO;2-B |display-authors=etal}}
- {{cite journal | vauthors=Davidsson P, Nilsson CL |title=Peptide mapping of proteins in cerebrospinal fluid utilizing a rapid preparative two-dimensional electrophoretic procedure and matrix-assisted laser desorption/ionization mass spectrometry |journal=Biochim. Biophys. Acta |volume=1473 |issue= 2–3 |pages= 391–9 |year= 2000 |pmid= 10594376 |doi= 10.1016/s0304-4165(99)00197-x}}
- {{cite journal | vauthors=Kennedy MW, Heikema AP, Cooper A |title=Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 35008–13 |year= 2001 |pmid= 11425849 |doi= 10.1074/jbc.C100301200 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Scherer SW, Cheung J, MacDonald JR |title=Human chromosome 7: DNA sequence and biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 |display-authors=etal}}
- {{cite journal | vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |display-authors=etal}}
- {{cite journal | vauthors=BURGI W, SCHMID K |title=Preparation and properties of Zn-alpha 2-glycoprotein of normal human plasma |journal=J. Biol. Chem. |volume=236 |issue= |pages= 1066–74 |year= 1998 |pmid= 13689030 |doi= }}
{{refend}}{{PDB Gallery|geneid=563}}{{gene-7-stub}} |