| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 is an enzyme that in humans is encoded by the B3GNT2 gene.[1][2][3]This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains.[3] References1. ^{{cite journal | vauthors = Zhou D, Dinter A, Gutierrez Gallego R, Kamerling JP, Vliegenthart JF, Berger EG, Hennet T | title = A β-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to β-1,3-galactosyltransferases | journal = Proc Natl Acad Sci U S A | volume = 96 | issue = 2 | pages = 406–11 |date=Mar 1999 | pmid = 9892646 | pmc = 15149 | doi =10.1073/pnas.96.2.406 }}
2. ^{{cite journal | vauthors = Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K | title = Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family | journal = J Biol Chem | volume = 276 | issue = 5 | pages = 3498–507 |date=May 2001 | pmid = 11042166 | pmc = | doi = 10.1074/jbc.M004800200 }}
3. ^1 {{cite web | title = Entrez Gene: B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10678| accessdate = }}
External links- {{UCSC gene info|B3GNT2}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Amado M, Almeida R, Schwientek T, Clausen H |title=Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions |journal=Biochim. Biophys. Acta |volume=1473 |issue= 1 |pages= 35–53 |year= 2000 |pmid= 10580128 |doi= 10.1016/S0304-4165(99)00168-3}}
- {{cite journal | vauthors=Ju T, Cummings RD |title=A unique molecular chaperone Cosmc required for activity of the mammalian core 1 β3-galactosyltransferase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16613–8 |year= 2003 |pmid= 12464682 |doi= 10.1073/pnas.262438199 | pmc=139192 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Isshiki S, Kudo T, Nishihara S |title=Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36611–20 |year= 2003 |pmid= 12855703 |doi= 10.1074/jbc.M302681200 |display-authors=etal}}
- {{cite journal | vauthors=Hayashi N, Nakamori S, Okami J |title=Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissue |journal=Pathobiology |volume=71 |issue= 1 |pages= 26–34 |year= 2004 |pmid= 14555842 |doi= 10.1159/000072959 |display-authors=etal}}
- {{cite journal | vauthors=Mare L, Trinchera M |title=Suppression of beta 1,3galactosyltransferase beta 3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans |journal=Eur. J. Biochem. |volume=271 |issue= 1 |pages= 186–94 |year= 2004 |pmid= 14686931 |doi=10.1046/j.1432-1033.2003.03919.x }}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 | pmc=395752 }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Zheng H, Li Y, Ji C |title=Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase |journal=Mol. Biol. Rep. |volume=31 |issue= 3 |pages= 171–5 |year= 2005 |pmid= 15560372 |doi=10.1023/B:MOLE.0000043552.32411.67 |display-authors=etal}}
- {{cite journal | vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 |display-authors=etal}}
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