| 词条 | Barakol |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 477370466 | IUPAC_name = 2,5-Dimethyl-3aH-pyrano[2,3,4-de]-1-benzopyran-3a,8-diol | image = Barakol_structure.png | width = 220 | tradename = | legal_status = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 24506-68-1 | ATC_prefix = none | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C13H12O4/c1-7-3-9-4-10(14)5-11-12(9)13(15,17-7)6-8(2)16-11/h3-6,14-15H,1-2H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = LVPNMZHEDIKUFK-UHFFFAOYSA-N | PubChem = 3080731 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 2338470 | C=13 | H=12 | O=4 | molecular_weight = 232.231 g/mol | smiles = CC2=Cc3cc(O)cc(c13)OC(C)=CC1(O)O2 }} Barakol is a compound found in the plant Senna siamea,[1] which is used in traditional herbal medicine. It has sedative and anxiolytic effects.[2][3]There are contradictory pharmacological research findings concerning the toxicity of Cassia siamea and the active ingredient Barakol. One pharmacological study has shown an hepatoxic effect of Barakol [4] while another study didn't show any toxic effect at a daily dosage intake.[5] Further research is needed to verify whether there are toxic effects of Barakol or not. References1. ^{{ cite journal |author1=Padumanonda, T. |author2=Gritsanapan, W. | title = Barakol Contents in Fresh and Cooked Senna siamea Leaves | journal = The Southeast Asian Journal of Tropical Medicine and Public Health | volume = 37 | issue = 2 | pages = 388–393 |date=March 2006 | pmid = 17125004 | doi= | url= }} {{sedative-stub}}2. ^{{cite journal |author1=Thongsaard, W. |author2=Pongsakorn, S. |author3=Sudsuang, R. |author4=Bennett, G. W. |author5=Kendall, D. A. |author6=Marsden, C. A. | title = Barakol, a Natural Anxiolytic, Inhibits Striatal Dopamine Release but Not Uptake in vitro | journal = European Journal of Pharmacology | volume = 319 | issue = 2-3 | pages = 157–164 |date=January 1997 | pmid = 9042586 | doi = 10.1016/S0014-2999(96)00850-3 | url = }} 3. ^{{ cite journal |author1=Sukma, M. |author2=Chaichantipyuth, C. |author3=Murakami, Y. |author4=Tohda, M. |author5=Matsumoto, K. |author6=Watanabe, H. | title = CNS Inhibitory Effects of Barakol, a Constituent of Cassia siamia Lamk | journal = Journal of Ethnopharmacology | volume = 83 | issue = 1-2 | pages = 87–94 |date=November 2002 | pmid = 12413711 | doi = 10.1016/S0378-8741(02)00206-4 | url = }} 4. ^{{ cite journal |author1=Hongsirinirachorn, M. |author2=Threeprasertsuk, S. |author3=Chutaputti, A. | title = Acute Hepatitis Associated with Barakol | journal = Journal of the Medical Association of Thailand = Chotmaihet Thangphaet | volume = 86 Suppl. 2 | issue = | pages = S484–489 |date=June 2003 | pmid = 12930029 | doi = | url = }} 5. ^ name=>{{ cite journal |author1=Wahjoedi, B. |author2=Pudjiastuti, |author3=Nuratmi, B. |author4=Sundari, D. |author5=Chozin, A. | title = TOKSISITAS SUBKRONIK EKSTRAK ETANOL DAUN JOHAR (CASSIA SIAMEA LAMK.) PADA TIKUS PUTIH, The subchronic toxicity study of the ethanolic extract of Cassia siamea lamk leaf (daun johar) on albino rats | journal = Bulletin of health research = Buletin Penelitian Kesehatan = National Institute of Health Research and Development - Ministry of Health of Republic of Indonesia | volume = 27 Suppl. 3 & 4 | issue = | pages = S325–332 |date = December 1999 | doi = | url =http://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/275/359 }} 2 : Sedatives|Anxiolytics |
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