| 词条 | Batanopride |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 461752878 | IUPAC_name = 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-(3-oxobutan-2-yloxy)benzamide | image = Batanopride.png | tradename = | pregnancy_category = | legal_status = Uncontrolled | routes_of_administration = Oral | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 102670-46-2 | ATC_prefix = none | ATC_suffix = | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 38594 | PubChem = 59692 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 1AT99K728N | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 53849 | smiles = Clc1cc(c(OC(C(=O)C)C)cc1N)C(=O)NCCN(CC)CC | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C17H26ClN3O3/c1-5-21(6-2)8-7-20-17(23)13-9-14(18)15(19)10-16(13)24-12(4)11(3)22/h9-10,12H,5-8,19H2,1-4H3,(H,20,23) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = ZYOJXUNLLOBURP-UHFFFAOYSA-N | C=17 | H=26 | Cl=1 | N=3 | O=3 | molecular_weight = 355.860 g/mol }}Batanopride (BMY-25,801) is an antiemetic drug of the benzamide class which acts as a selective 5-HT3 receptor antagonist.[1] It was trialled to reduce nausea during cancer chemotherapy, but was never approved for medical use due to dose-limiting side effects including hypotension and long QT syndrome.[2] References1. ^Gylys JA, Wright RN, Nicolosi WD, Buyniski JP, Crenshaw RR. BMY-25801, an antiemetic agent free of D2-dopamine receptor antagonist properties. Journal of Pharmacology and Experimental Therapeutics. 1988 Mar;244(3):830-7. {{PMID|2978041}} {{Antiemetics}}{{Serotonergics}}{{gastrointestinal-drug-stub}}2. ^Fleming GF, Vokes EE, McEvilly JM, Janisch L, Francher D, Smaldone L. Double-blind, randomized crossover study of metoclopramide and batanopride for prevention of cisplatin-induced emesis. Cancer Chemotherapy and Pharmacology. 1991;28(3):226-7. {{PMID|1855280}} 6 : 5-HT3 antagonists|Antiemetics|Benzamides|Phenol ethers|Anilines|Chloroarenes |
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