| 词条 | BAZ1A |
| 释义 |
StructureThe protein encoded by this gene belongs to a family of proteins which includes BAZ1B, BAZ2A, and BAZ2B. All family members contain the following domains and structural motifs:[1]
FunctionBAZ1A along with SMARCA5, POLE3, and CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex.[3][4] The purified CHRAC complex can mobilize nucleosomes into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent.[4] Furthermore, the BAZ1A-SMARCA5 complex enables DNA replication through highly condensed regions of chromatin.[5] InteractionsBAZ1A has been shown to interact with SMARCA5[3][4][6][7][8] and SATB1.[7] References1. ^1 {{cite journal |vauthors=Jones MH, Hamana N, Nezu J, Shimane M | title = A novel family of bromodomain genes | journal = Genomics | volume = 63 | issue = 1 | pages = 40–5 |date=Apr 2000 | pmid = 10662543 | pmc = | doi = 10.1006/geno.1999.6071 }} {{Gene-14-stub}}2. ^{{Cite web| title = Entrez Gene: BAZ1A bromodomain adjacent to zinc finger domain, 1A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11177| accessdate = }} 3. ^1 {{cite journal |vauthors=Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R | title = A family of chromatin remodeling factors related to Williams syndrome transcription factor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 3 | pages = 1038–43 |date=February 2000 | pmid = 10655480 | pmc = 15513 | url = http://www.pnas.org/cgi/pmidlookup?view=long&pmid=10655480| doi = 10.1073/pnas.97.3.1038 | bibcode = 2000PNAS...97.1038B }} 4. ^1 2 {{cite journal |vauthors=Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD | title = HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins | journal = EMBO J. | volume = 19 | issue = 13 | pages = 3377–87 |date=July 2000 | pmid = 10880450 | pmc = 313940 | doi = 10.1093/emboj/19.13.3377 | url = }} 5. ^{{cite journal |vauthors=Collins N, Poot RA, Kukimoto I, García-Jiménez C, Dellaire G, Varga-Weisz PD | title = An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin | journal = Nat. Genet. | volume = 32 | issue = 4 | pages = 627–32 |date=December 2002 | pmid = 12434153 | doi = 10.1038/ng1046 | url = }} 6. ^{{cite journal |last=Bozhenok |first=Ludmila |authorlink= |author2=Wade Paul A |author3=Varga-Weisz Patrick |date=May 2002 |title=WSTF–ISWI chromatin remodeling complex targets heterochromatic replication foci |journal=EMBO J. |volume=21 |issue=9 |pages=2231–41 |publisher= |location = England| issn = 0261-4189| pmid = 11980720 |doi = 10.1093/emboj/21.9.2231 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=125993 }} 7. ^1 {{cite journal |last=Yasui |first=Dag |authorlink= |author2=Miyano Masaru |author3=Cai Shutao |author4=Varga-Weisz Patrick |author5=Kohwi-Shigematsu Terumi |date=Oct 2002 |title=SATB1 targets chromatin remodelling to regulate genes over long distances |journal=Nature |volume=419 |issue=6907 |pages=641–5 |publisher= |location = England| issn = 0028-0836| pmid = 12374985 |doi = 10.1038/nature01084 | bibcode =2002Natur.419..641Y | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }} 8. ^{{cite journal |last=Hakimi |first=Mohamed-Ali |authorlink= |author2=Bochar Daniel A |author3=Schmiesing John A |author4=Dong Yuanshu |author5=Barak Orr G |author6=Speicher David W |author7=Yokomori Kyoko |author8=Shiekhattar Ramin |date=Aug 2002 |title=A chromatin remodelling complex that loads cohesin onto human chromosomes |journal=Nature |volume=418 |issue=6901 |pages=994–8 |publisher= |location = England| issn = 0028-0836| pmid = 12198550 |doi = 10.1038/nature01024 | bibcode =2002Natur.418..994H | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }} 1 : Genes on human chromosome 14 |
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